Antibody–drug conjugates come of age in oncology

C Dumontet, JM Reichert, PD Senter… - Nature Reviews Drug …, 2023 - nature.com
Antibody–drug conjugates (ADCs) combine the specificity of monoclonal antibodies with the
potency of highly cytotoxic agents, potentially reducing the severity of side effects by …

Clinical and translational advances in ovarian cancer therapy

PA Konstantinopoulos, UA Matulonis - Nature Cancer, 2023 - nature.com
Ovarian cancer is an aggressive disease that is frequently detected at advanced stages and
is initially very responsive to platinum-based chemotherapy. However, the majority of …

Optimizing the safety of antibody–drug conjugates for patients with solid tumours

P Tarantino, B Ricciuti, SM Pradhan… - Nature reviews Clinical …, 2023 - nature.com
Over the past 5 years, improvements in the design of antibody–drug conjugates (ADCs)
have enabled major advances that have reshaped the treatment of several advanced-stage …

The evolving landscape of antibody–drug conjugates: In depth analysis of recent research progress

JM Sasso, R Tenchov, R Bird, KA Iyer… - Bioconjugate …, 2023 - ACS Publications
Antibody–drug conjugates (ADCs) are targeted immunoconjugate constructs that integrate
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …

ADCdb: the database of antibody–drug conjugates

L Shen, X Sun, Z Chen, Y Guo, Z Shen… - Nucleic Acids …, 2024 - academic.oup.com
Antibody-drug conjugates (ADCs) are a class of innovative biopharmaceutical drugs, which,
via their antibody (mAb) component, deliver and release their potent warhead (aka. payload) …

Clinical perspective: antibody-drug conjugates for the treatment of HER2-positive breast cancer

Z Najminejad, F Dehghani, Y Mirzaei, AH Mer… - Molecular Therapy, 2023 - cell.com
Antibody-drug conjugates (ADCs) are a promising class of cancer biopharmaceuticals that
exploit the specificity of a monoclonal antibody (mAb) to selectively deliver highly cytotoxic …

Exploration of the antibody–drug conjugate clinical landscape

H Maecker, V Jonnalagadda, S Bhakta… - MAbs, 2023 - Taylor & Francis
The antibody–drug conjugate (ADC) field has undergone a renaissance, with substantial
recent developmental investment and subsequent drug approvals over the past 6 years. In …

Mechanisms of resistance to antibody-drug conjugates

R Khoury, K Saleh, N Khalife, M Saleh… - International journal of …, 2023 - mdpi.com
The treatment of cancer patients has dramatically changed over the past decades with the
advent of monoclonal antibodies, immune-checkpoint inhibitors, bispecific antibodies, and …

[HTML][HTML] The evolving landscape of antibody-drug conjugates in gynecologic cancers

A Tolcher, E Hamilton, RL Coleman - Cancer treatment reviews, 2023 - Elsevier
Despite significant advances in the treatment of cervical, ovarian, and uterine cancers with
the approvals of checkpoint and PARP inhibitors into standard treatment, patients with …

Mechanisms of resistance to antibody–drug conjugates

RO Abelman, B Wu, LM Spring, LW Ellisen, A Bardia - Cancers, 2023 - mdpi.com
Simple Summary Antibody–drug conjugates (ADCs) are a growing class of therapies that
aim to delivery therapy more efficiently, with fewer side effects, than conventional …