Physiological and therapeutic effects of carnosine on cardiometabolic risk and disease

E Baye, B Ukropcova, J Ukropec, A Hipkiss, G Aldini… - Amino acids, 2016 - Springer
Abstract Obesity, type 2 diabetes (T2DM) and cardiovascular disease (CVD) are the most
common preventable causes of morbidity and mortality worldwide. They represent major …

L-carnosine and its derivatives as new therapeutic agents for the prevention and treatment of vascular complications of diabetes

S Menini, C Iacobini, CB Fantauzzi… - Current Medicinal …, 2020 - ingentaconnect.com
Vascular complications are among the most serious manifestations of diabetes.
Atherosclerosis is the main cause of reduced life quality and expectancy in diabetics …

Thyroid hormone role in metabolic status and economic beneficial features formation in replacement gilts of different breeds

MA Derkho, SA Gritsenko, DS Vilver, TI Sereda… - Periodico Tche …, 2019 - elibrary.ru
The peculiarities of pituitary-thyroid regulation of the protein metabolism in the replacement
gilts of different bred and the correlations between the hormone levels and the blood …

[HTML][HTML] Improved satellite cell proliferation induced by l-carnosine benefits muscle growth of pigs in part through activation of the akt/mtor/s6k signaling pathway

Y Liu, W Shen, T Liu, R Mosenthin, Y Bao, P Chen… - Agriculture, 2022 - mdpi.com
(1) Background: L-carnosine (β-alanyl-L-histidine), a natural dipeptide, exists at relatively
high concentrations in skeletal muscles, and has been shown to protect cells from adverse …

Effects of supplementation with carnosine and other histidine-containing dipeptides on chronic disease risk factors and outcomes: protocol for a systematic review of …

K Menon, A Mousa, B de Courten - BMJ open, 2018 - bmjopen.bmj.com
Introduction Ageing of populations globally, coupled with the obesity epidemic, has resulted
in the rising prevalence of chronic diseases including diabetes, cardiovascular diseases …

[HTML][HTML] Characterisation of intracellular molecular mechanisms modulated by carnosine in porcine myoblasts under basal and oxidative stress conditions

MF Palin, J Lapointe, C Gariépy, D Beaudry, C Kalbe - PLoS One, 2020 - journals.plos.org
Carnosine is a naturally occurring histidine-containing dipeptide present at high
concentration in mammalian skeletal muscles. Carnosine was shown to affect muscle …

[HTML][HTML] Dietary supplementation with pioglitazone hydrochloride and L-carnosine improves the growth performance, muscle fatty acid profiles and shelf life of yellow …

F Zhang, C Jin, X Wang, H Yan, H Tan, C Gao - Animal Nutrition, 2021 - Elsevier
The present study aimed to investigate the effects of dietary pioglitazone hydrochloride
(PGZ) and l-carnosine (LC) supplementation on the growth performance, meat quality …

[HTML][HTML] A global Cndp1-knock-out selectively increases renal carnosine and anserine concentrations in an age-and gender-specific manner in mice

T Weigand, F Colbatzky, T Pfeffer, SF Garbade… - International journal of …, 2020 - mdpi.com
Carnosinase 1 (CN1) is encoded by the Cndp1 gene and degrades carnosine and anserine,
two natural histidine-containing dipeptides. In vitro and in vivo studies suggest carnosine …

Use of carnosine in the prevention of cardiometabolic risk factors in overweight and obese individuals: study protocol for a randomised, double-blind placebo …

K Menon, JD Cameron, M de Courten, B de Courten - BMJ open, 2021 - bmjopen.bmj.com
Introduction Carnosine, an over the counter food supplement, has been shown to improve
glucose metabolism as well as cardiovascular risk factors in animal and human studies …

[HTML][HTML] Effect of muscle fibre types and carnosine levels on the expression of carnosine-related genes in pig skeletal muscle

C Kalbe, K Metzger, C Gariépy, MF Palin - Histochemistry and Cell Biology, 2023 - Springer
It is generally accepted that carnosine (β-alanyl-l-histidine) content is higher in glycolytic
than in oxidative muscle fibres, but the underlying mechanisms responsible for this …