The balance between bone forming cells (osteoblasts/osteocytes) and bone resorbing cells
(osteoclasts) plays a crucial role in tissue homeostasis and bone repair. Several hormones …

Denosumab, a fully humanized monoclonal neutralizing antibody, inhibits activation of the
RANK/RANKL/OPG signaling pathway through competitive binding with RANKL, thereby …

Metastatic tumor deposits in bone marrow elicit differential bone responses that vary with the
type of malignancy. This results in either sclerotic, lytic, or mixed bone lesions, which can …

Background Late-stage breast cancer preferentially metastasises to bone; despite advances
in targeted therapies, this condition remains incurable. The lack of clinically relevant models …

Objective: Using CT texture analysis and machine learning methods, this study aims to
distinguish the lesions imaged via 68Ga-prostate-specific membrane antigen (PSMA) …

Simple Summary KRAS G12C mutations are important oncogenic mutations in lung cancer
that can now be targeted by allosteric small molecule inhibitors. We assessed the imaging …

Bone tissues are the main metastatic sites of many cancers, and bone metastasis is an
important cause of death. When bone metastasis occurs, dynamic interactions between …

Skeletal involvement is a frequent and troublesome complication in advanced cancers. In
the process of tumor cells homing to the skeleton to form bone metastases (BM), different …

Accumulating discoveries highlight the importance of interaction between marrow stromal
cells and cancer cells for bone metastasis. Bone is the most common metastatic site of …

Simple Summary Normal blood cells are formed in the bone marrow by a process called
hematopoiesis. This process is supported by a network of non-hematopoietic cells including …