Recent advances in amorphous solid dispersions: preformulation, formulation strategies, technological advancements and characterization
Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …
Amorphous solid dispersions: role of the polymer and its importance in physical stability and in vitro performance
Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …
for delivering amorphous drugs with poor water solubilities, and they have gained great …
Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of …
Fungal infections affect millions of people globally and are often unreceptive to conventional
topical or oral preparations because of low drug bioavailability at the infection site, lack of …
topical or oral preparations because of low drug bioavailability at the infection site, lack of …
Liquid–liquid phase separation drug aggregate: Merit for oral delivery of amorphous solid dispersions
P Zhao, W Han, Y Shu, M Li, Y Sun, X Sui, B Liu… - Journal of Controlled …, 2023 - Elsevier
As a promising strategy, amorphous solid dispersion has been extensively employed in
improving the oral bioavailability of insoluble drugs. Despite the numerous advantages, the …
improving the oral bioavailability of insoluble drugs. Despite the numerous advantages, the …
[HTML][HTML] In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices
The in-situ formation of nanoparticles from polymer-based solid medicines, although
previously described, has been overlooked despite its potential to interfere with oral drug …
previously described, has been overlooked despite its potential to interfere with oral drug …
Increasing cellular uptake and permeation of curcumin using a novel polymer-surfactant formulation
Z Liu, AB Lansley, TN Duong, JD Smart, AS Pannala - Biomolecules, 2022 - mdpi.com
Several therapeutically active molecules are poorly water-soluble, thereby creating a
challenge for pharmaceutical scientists to develop an active solution for their oral drug …
challenge for pharmaceutical scientists to develop an active solution for their oral drug …
Enteric Polymer–Based Amorphous Solid Dispersions Enhance Oral Absorption of the Weakly Basic Drug Nintedanib via Stabilization of Supersaturation
Y Qin, C Xiao, X Li, J Huang, L Si, M Sun - Pharmaceutics, 2022 - mdpi.com
The pH–induced crystallization of weakly basic drugs in the small intestine limits oral
bioavailability. In this study, we investigated the solubilization and inhibitory effects on …
bioavailability. In this study, we investigated the solubilization and inhibitory effects on …
Supersaturable diacyl phospholipid dispersion for improving oral bioavailability of brick dust molecule: A case study of Aprepitant
This study aims to investigate the potential use of polymer inclusion in the phospholipid-
based solid dispersion approach for augmenting the biopharmaceutical performance of …
based solid dispersion approach for augmenting the biopharmaceutical performance of …
Co-amorphous systems using epigallocatechin-3-gallate as a co-former: Stability, in vitro dissolution, in vivo bioavailability and underlying molecular mechanisms
J Chen, H Li, X Li, D Yuan, H Cheng, Y Ke… - European Journal of …, 2022 - Elsevier
Co-amorphous strategy has been extensively investigated to improve the dissolution of
hydrophobic drugs. Here, epigallocatechin-3-gallate (EGCG) was exploited as a co-former …
hydrophobic drugs. Here, epigallocatechin-3-gallate (EGCG) was exploited as a co-former …
Detecting crystallinity in amorphous solid dispersions using dissolution testing: considerations on properties of drug substance, drug product, and selection of …
Dissolution testing has long been used to monitor product quality. Its role in quality control of
amorphous solid dispersion (ASD) formulations is relatively new. In the presence of the …
amorphous solid dispersion (ASD) formulations is relatively new. In the presence of the …