Cryptococcus neoformans (C. neoformans) is a pathogenic fungus with a global distribution.
Humans become infected by inhaling the fungus from the environment, and the fungus …

In recent years it has become evident that the structural polysaccharide chitin is synthesized
from a family of enzymes encoded by multiple CHS chitin synthase genes, and regulated by …

Cryptococcus is a unique environmental fungus. Among the more than three dozen species
of Cryptococcus, only C. neoformans and C. gattii commonly cause disease. Although many …

Cryptococcus neoformans is a major fungal pathogen that disseminates to the central
nervous system (CNS) to cause fatal meningoencephalitis, but little is known about immune …

The vast majority of infection with cryptococcal species occurs with Cryptococcus
neoformans in the severely immunocompromised. A significant exception to this is the …

Aspergillus (A.) fumigatus is an opportunistic fungal mold inducing invasive aspergillosis (IA)
in immunocompromised patients. Although antifungal activity of human natural killer (NK) …

Cryptococcus neoformans is a leading cause of life-threatening fungal infection in
immunocompromised patients. Inositol-phosphoryl ceramide synthase 1 (Ipc1) is a fungus …

After intratracheal inoculation of the AIDS-associated pathogen Cryptococcus neoformans,
12-wk survival was> 90% for CCR5+/+ mice but< 25% for CCR5−/− mice. There were no …

The development of T1-cell-mediated immunity is required to clear a pulmonary
Cryptococcus neoformans infection. The objective of these studies was to determine the …

Infection of C57BL/6 mice with the moderately virulent Cryptococcus neoformans strain 52D
models the complex adaptive immune response observed in HIV-negative patients with …