A roadmap to increase diversity in genomic studies

S Fatumo, T Chikowore, A Choudhury, M Ayub… - Nature medicine, 2022 - nature.com
Two decades ago, the sequence of the first human genome was published. Since then,
advances in genome technologies have resulted in whole-genome sequencing and …

Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease

E Peprah, H Xu, F Tekola-Ayele, CD Royal - Public Health Genomics, 2015 - karger.com
Genomic research is one of the tools for elucidating the pathogenesis of diseases of global
health relevance and paving the research dimension to clinical and public health translation …

African genetic diversity: implications for cytochrome P450-mediated drug metabolism and drug development

I Rajman, L Knapp, T Morgan, C Masimirembwa - EBioMedicine, 2017 - thelancet.com
Genetic diversity is greater in Africa than in other continental populations. Genetic variability
in genes encoding drug metabolizing enzymes may contribute to the high numbers of …

[PDF][PDF] Three decades of ethical, legal, and social implications research: looking back to chart a path forward

DD Dolan, SSJ Lee, MK Cho - Cell genomics, 2022 - cell.com
More than thirty years ago in the United States, the National Center for Human Genome
Research (NCHGR) at the National Institutes of Health (NIH) and its partner in the Human …

Regulation of genomic and biobanking research in Africa: a content analysis of ethics guidelines, policies and procedures from 22 African countries

J de Vries, SN Munung, A Matimba, S McCurdy… - BMC medical …, 2017 - Springer
Background The introduction of genomics and biobanking methodologies to the African
research context has also introduced novel ways of doing science, based on values of …

Boots on the ground in Africa's ancient DNA 'revolution': archaeological perspectives on ethics and best practices

ME Prendergast, E Sawchuk - Antiquity, 2018 - cambridge.org
Recent methodological advances have increased the pace and scale of African ancient
DNA (aDNA) research, inciting a rush to sample broadly from museum collections, and …

The global spectrum of protein-coding pharmacogenomic diversity

GEB Wright, B Carleton, MR Hayden… - The pharmacogenomics …, 2018 - nature.com
Differences in response to medications have a strong genetic component. By leveraging
publically available data, the spectrum of such genomic variation can be investigated …

A framework for tiered informed consent for health genomic research in Africa

V Nembaware, K Johnston, AA Diallo, MJ Kotze… - Nature Genetics, 2019 - nature.com
A generic framework for providing participant information and implementing a tiered consent
process for health genomic research in Africa can help to harness global health benefits …

Cybersecurity in health–disentangling value tensions

M Loi, M Christen, N Kleine, K Weber - Journal of Information …, 2019 - emerald.com
Purpose Cybersecurity in healthcare has become an urgent matter in recent years due to
various malicious attacks on hospitals and other parts of the healthcare infrastructure. The …

Obtaining informed consent for genomics research in Africa: analysis of H3Africa consent documents

NS Munung, P Marshall, M Campbell, K Littler… - Journal of Medical …, 2016 - jme.bmj.com
Background The rise in genomic and biobanking research worldwide has led to the
development of different informed consent models for use in such research. This study …