Objective: Obesity is characterized by a state of chronic, low-intensity systemic inflammation
frequently associated with insulin resistance and dyslipidemia. Materials and methods …

Results: After standardization for age, sex, country income and urban/rural location, the
proportion with obesity (body mass index⩾ 30 kg m− 2) increased from 15.7% in 40 831 …

Stefan R Bornstein & Julio Licinio government research institutes, academia and universities
with hospitals and clinical care. Although the necessity for such an integration may seem …

We examined whether behavioral problems in childhood and adolescence are associated
with young adults' BMI and obesity, and tested whether childhood behavioral problems have …

Recently, the pathophysiological overlap between metabolic and mental disorders has
received increased recognition. Zebrafish (Danio rerio) are rapidly becoming a popular …

BackgroundThe present study aimed to (a) characterize 10-year trajectory patterns of
depressive symptoms and (b) investigate the association between depressive trajectory and …

Type 1A (immune-mediated) and type 2 diabetes mellitus are two of the most common
severe chronic illnesses, affecting over 230 million people worldwide with an estimated …

Objective Childhood trauma is known to be related to inflammatory processes in adulthood,
but underlying psychological/behavioral mechanisms have not been fully characterized. To …

Background Evidence for a role of leptin in depression is limited and conflicting.
Inconclusive findings may be explained by the complex effect of obesity on leptin signaling …

We performed gene–environment interaction genome-wide association analysis (G× E
GWAS) to identify SNPs whose effects on metabolic traits are modified by chronic …