Previous efforts aimed at attributing discrete behavioral functions to cortical cholinergic
afferents have not resulted in a generally accepted hypothesis about the behavioral …

Cortical neuromodulatory transmitter systems refer to those classical neurotransmitters such
as acetylcholine and monoamines, which share a number of common features. For instance …

A widespread distribution of dopamine D 1 receptors in the neocortex is well recognized.
However, the presence of dopamine D 2 receptors in this structure has only recently been …

The basal forebrain cholinergic neurons (BFCN) provide the primary source of cholinergic
innervation of the human cerebral cortex. They are involved in the cognitive processes of …

Evidence from lesion and cortical-slice studies implicate the neocortical cholinergic system
in the modulation of sensory, attentional and memory processing. In this review we consider …

Muscarinic m1 receptors traditionally are considered to be postsynaptic to cholinergic fibers,
while m2 receptors are largely presynaptic receptors associated with axons. We have …

Publisher Summary This chapter discusses the neuroanatomy of cortical cholinergic
innervation in the human brain and its implications for behavior. The cholinergic innervation …

Motor deficits affect patients with Alzheimer's disease only at later stages. Recent studies
demonstrate that the primary motor cortex is affected by neuronal degeneration …

Publisher Summary The cholinergic innervation of the cerebral cortex has now become one
of the most dynamic areas of research and offers exciting opportunities for exploring the …

Recently, neuropathological studies have shown an important motor cortex involvement in
Alzheimer's disease (AD), even in its early stages, despite the lack of clinically evident motor …