Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease
continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodelling …

Calcific aortic valve disease (CAVD) is a common acquired valvulopathy, which carries a
high burden of mortality. Chronic inflammation has been postulated as the predominant …

Background TAMs (tumor-associated macrophages) infiltration promotes the progression of
esophageal cancer (EC). However, the underlying mechanisms remain unclear. Methods …

Background Calcific aortic valve disease (CAVD) is the most prevalent valvular disease and
has high morbidity and mortality. CAVD is characterized by complex pathophysiological …

Calcified aortic valve disease (CAVD) is a major non-rheumatic heart valve disease in the
world, with a high mortality rate and without suitable pharmaceutical therapy due to its …

Doxorubicin (DOX)-based chemotherapy is widely used to treat malignant tumors; however,
the cardiotoxicity induced by DOX restricts its clinical usage. A therapeutic dose of DOX can …

Rationale: Calcific aortic valve disease (CAVD) is a leading cause of cardiovascular
mortality and morbidity with increasing prevalence and incidence. The pathobiology of …

Objective Calcific aortic valve disease (CAVD) predominantly affects the elderly and
currently lacks effective medical treatments. Nesfatin-1, a peptide derived from the cleavage …

Aims The incidence of calcific aortic valve disease (CAVD) has risen over the last decade
and is expected to continue rising; however, pharmacological approaches have proven …

Patients with chronic kidney disease (CKD) are at an increased cardiovascular risk
compared with the general population, which is driven, at least in part, by mechanisms that …