Despite extensive research, the current theories on serotonergic dysfunctions and cortisol
hypersecretion do not provide sufficient explanations for the nature of depression. Rational …

Our understanding of the pathogenesis of diseases has advanced enormously in recent
decades. As a consequence, drug discovery has gradually shifted from an entirely …

Coenzyme Q (CoQ) is present in all cells and membranes and in addition to be a member of
the mitochondrial respiratory chain it has also several other functions of great importance for …

Sporadic amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
diseases; most patients die within 3 to 4 years after symptom onset. Oxidative stress is a …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of adult life, causing
weakness and wasting of voluntary muscles, associated in about 50% of cases with a …

Cellular antioxidants are known to change their redox state, and they can be targeted for
destruction, regulate oxidative processes involved in signal transduction, effect gene …

Brain aging is characterized by the continual concession to battle against insults
accumulated over the years. One of the major insults is oxidative stress, which is the inability …

Intracortical microelectrode arrays (MEAs) are used to record neural activity. However, their
implantation initiates a neuroinflammatory cascade, involving the accumulation of reactive …

The neuroprotective effects of protocatechuic acid (PCA), a phenolic compound isolated
from the kernels of Alpinia oxyphylla, on hydrogen peroxide (H2O2)-induced apoptosis and …

Evidence of oxidative stress is apparent in both acute and chronic neurodegenerative
diseases, such as stroke, Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) …