Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity

B Zingales - Acta tropica, 2018 - Elsevier
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …

Novel data‐mining methodologies for adverse drug event discovery and analysis

R Harpaz, W DuMouchel, NH Shah… - Clinical …, 2012 - Wiley Online Library
An important goal of the health system is to identify new adverse drug events (ADEs) in the
postapproval period. Data‐mining methods that can transform data into meaningful …

[PDF][PDF] FDA Modernization Act 2.0: transitioning beyond animal models with human cells, organoids, and AI/ML-based approaches

PJH Zushin, S Mukherjee… - Journal of Clinical …, 2023 - Am Soc Clin Investig
The discovery and generation of effective therapeutics to combat disease lies at the heart of
biomedical research. Preclinical studies form the foundation of potential disease treatments …

Genophenotypic factors and pharmacogenomics in adverse drug reactions

R Cacabelos, V Naidoo, L Corzo, N Cacabelos… - International journal of …, 2021 - mdpi.com
Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …

Genome-wide association studies in pharmacogenomics

AK Daly - Nature Reviews Genetics, 2010 - nature.com
Genome-wide association (GWA) studies for pharmacogenomics-related traits are
increasingly being performed to identify loci that affect either drug response or susceptibility …

Ziziphora clinopodioides Lam leaves aqueous extract mediated synthesis of zinc nanoparticles and their antibacterial, antifungal, cytotoxicity, antioxidant, and cutaneous wound healing …

B Mahdavi, S Saneei, M Qorbani… - Applied …, 2019 - Wiley Online Library
LamZiziphora clinopodioides Biosynthesis of metal nanoparticles using plant medicine is
under exploration is due to wide biomedica applications and research interest in …

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion

DB Kell, SG Oliver - Frontiers in pharmacology, 2014 - frontiersin.org
One approach to experimental science involves creating hypotheses, then testing them by
varying one or more independent variables, and assessing the effects of this variation on the …

Leishmaniasis: prevention, parasite detection and treatment

T Kobets, I Grekov, M Lipoldova - Current Medicinal Chemistry, 2012 - ingentaconnect.com
Leishmaniasis remains a public health problem worldwide, affecting approximately 12
million people in 88 countries; 50 000 die of it each year. The disease is caused by …

Adverse drug reactions and organ damage: The liver

A Licata - European journal of internal medicine, 2016 - Elsevier
Drug-induced liver injury (DILI) is among the most challenging acute or chronic liver
conditions to be handled by physicians. Despite its low incidence in the general population …

Chronotherapy and the molecular clock: Clinical implications in oncology

PF Innominato, FA Lévi, GA Bjarnason - Advanced drug delivery reviews, 2010 - Elsevier
The circadian timing system drives daily rhythmic changes in drug metabolism and controls
rhythmic events in cell cycle, DNA repair, apoptosis, and angiogenesis in both normal tissue …