Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity
B Zingales - Acta tropica, 2018 - Elsevier
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …
Novel data‐mining methodologies for adverse drug event discovery and analysis
An important goal of the health system is to identify new adverse drug events (ADEs) in the
postapproval period. Data‐mining methods that can transform data into meaningful …
postapproval period. Data‐mining methods that can transform data into meaningful …
[PDF][PDF] FDA Modernization Act 2.0: transitioning beyond animal models with human cells, organoids, and AI/ML-based approaches
PJH Zushin, S Mukherjee… - Journal of Clinical …, 2023 - Am Soc Clin Investig
The discovery and generation of effective therapeutics to combat disease lies at the heart of
biomedical research. Preclinical studies form the foundation of potential disease treatments …
biomedical research. Preclinical studies form the foundation of potential disease treatments …
Genophenotypic factors and pharmacogenomics in adverse drug reactions
R Cacabelos, V Naidoo, L Corzo, N Cacabelos… - International journal of …, 2021 - mdpi.com
Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …
illness in developed countries. ADRs show differential features depending upon genotype …
Genome-wide association studies in pharmacogenomics
AK Daly - Nature Reviews Genetics, 2010 - nature.com
Genome-wide association (GWA) studies for pharmacogenomics-related traits are
increasingly being performed to identify loci that affect either drug response or susceptibility …
increasingly being performed to identify loci that affect either drug response or susceptibility …
Ziziphora clinopodioides Lam leaves aqueous extract mediated synthesis of zinc nanoparticles and their antibacterial, antifungal, cytotoxicity, antioxidant, and cutaneous wound healing …
B Mahdavi, S Saneei, M Qorbani… - Applied …, 2019 - Wiley Online Library
LamZiziphora clinopodioides Biosynthesis of metal nanoparticles using plant medicine is
under exploration is due to wide biomedica applications and research interest in …
under exploration is due to wide biomedica applications and research interest in …
How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion
One approach to experimental science involves creating hypotheses, then testing them by
varying one or more independent variables, and assessing the effects of this variation on the …
varying one or more independent variables, and assessing the effects of this variation on the …
Leishmaniasis: prevention, parasite detection and treatment
T Kobets, I Grekov, M Lipoldova - Current Medicinal Chemistry, 2012 - ingentaconnect.com
Leishmaniasis remains a public health problem worldwide, affecting approximately 12
million people in 88 countries; 50 000 die of it each year. The disease is caused by …
million people in 88 countries; 50 000 die of it each year. The disease is caused by …
Adverse drug reactions and organ damage: The liver
A Licata - European journal of internal medicine, 2016 - Elsevier
Drug-induced liver injury (DILI) is among the most challenging acute or chronic liver
conditions to be handled by physicians. Despite its low incidence in the general population …
conditions to be handled by physicians. Despite its low incidence in the general population …
Chronotherapy and the molecular clock: Clinical implications in oncology
PF Innominato, FA Lévi, GA Bjarnason - Advanced drug delivery reviews, 2010 - Elsevier
The circadian timing system drives daily rhythmic changes in drug metabolism and controls
rhythmic events in cell cycle, DNA repair, apoptosis, and angiogenesis in both normal tissue …
rhythmic events in cell cycle, DNA repair, apoptosis, and angiogenesis in both normal tissue …