Vaccination with Sabin, a live attenuated oral polio vaccine (OPV), results in robust intestinal
and humoral immunity and has been key to controlling poliomyelitis. As with any RNA virus …

Poliomyelitis is caused by Poliovirus, a member of a large group of enteroviruses. Vaccine-
derived polioviruses (VDPVs) stem from mutated live poliovirus, which is contained in the …

Developing effective vaccines against viral infections have significant impacts on
development, prosperity and well-being of human populations. Thus, successful vaccines …

Background Novel oral polio vaccine type 2 (nOPV2) has been used to interrupt circulating
vaccine-derived poliovirus type 2 outbreaks following its WHO emergency use listing. This …

There is an increasing burden of circulating vaccine-derived polioviruses (cVDPVs) due to
the continued use of oral poliovirus vaccine (OPV). However, the informativeness of routine …

Enteroviruses are important human pathogens with diverse serotypes, posing a major
challenge to develop vaccines for individual serotypes, the success of polio vaccines in …

This chapter provides perspective on the routes of vaccine administration, comparing
invasive and noninvasive delivery methods. We begin with an analysis of the most …

Vaccination with Sabin oral poliovirus vaccine (OPV) results in robust intestinal and humoral
immunity and has been key to controlling poliomyelitis. However, as with any RNA virus …

The COVID-19 pandemic underscores the critical need for effective vaccines against SARS-
CoV-2. This thesis investigates diverse aspects of SARS-CoV-2 vaccine development …

The connecting thread through all chapters of this dissertation is the structural analysis of
antibody fragment complexed with non-enveloped viruses and mapping of the resulting …