Gut microbiota and microbial metabolism in early risk of cardiometabolic disease

CL Gabriel, JF Ferguson - Circulation Research, 2023 - Am Heart Assoc
Cardiometabolic disease comprises cardiovascular and metabolic dysfunction and
underlies the leading causes of morbidity and mortality, both within the United States and …

The microbiome as a major function of the gastrointestinal tract and its implication in micronutrient metabolism and chronic diseases

D Lin, DM Medeiros - Nutrition Research, 2023 - Elsevier
The composition and function of microbes harbored in the human gastrointestinal lumen
have been underestimated for centuries because of the underdevelopment of nucleotide …

[HTML][HTML] A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning

T Vatanen, QY Ang, L Siegwald, SA Sarker, CI Le Roy… - Cell, 2022 - cell.com
The gut microbiome has an important role in infant health and development. We
characterized the fecal microbiome and metabolome of 222 young children in Dhaka …

The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota l-carnitine catabolism

JA Buffa, KA Romano, MF Copeland, DB Cody… - Nature …, 2022 - nature.com
The heightened cardiovascular disease (CVD) risk observed among omnivores is thought to
be linked, in part, to gut microbiota-dependent generation of trimethylamine-N-oxide (TMAO) …

Atherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation

S Panyod, WK Wu, PC Chen, KV Chong… - NPJ biofilms and …, 2022 - nature.com
Cardiovascular disease (CVD) is strongly associated with the gut microbiota and its
metabolites, including trimethylamine-N-oxide (TMAO), formed from metaorganismal …

Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria

C Li, M Stražar, AMT Mohamed, JA Pacheco… - Cell, 2024 - cell.com
Accumulating evidence suggests that cardiovascular disease (CVD) is associated with an
altered gut microbiome. Our understanding of the underlying mechanisms has been …

Implications of trimethylamine N-oxide (TMAO) and betaine in human health: beyond being osmoprotective compounds

A Ilyas, YS Wijayasinghe, I Khan… - Frontiers in Molecular …, 2022 - frontiersin.org
Osmolytes are naturally occurring small molecular weight organic molecules, which are
accumulated in large amounts in all life forms to maintain the stability of cellular proteins and …

Inactivation of the antidiabetic drug acarbose by human intestinal microbial-mediated degradation

J Tian, C Li, Z Dong, Y Yang, J Xing, P Yu, Y Xin… - Nature …, 2023 - nature.com
Drugs can be modified or degraded by the gut microbiota, which needs to be considered in
personalized therapy. The clinical efficacy of the antidiabetic drug acarbose, an inhibitor of α …

[HTML][HTML] Advances in the integration of metabolomics and metagenomics for human gut microbiome and their clinical applications

F Puig-Castellví, R Pacheco-Tapia, M Deslande… - TrAC Trends in …, 2023 - Elsevier
The human microbiome and its metabolic output play an important role in shaping human
health and disease. The host-microbe crosstalk is often characterised using metabolomics …

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition

I Zarei, VM Koistinen, M Kokla, A Klåvus, AF Babu… - Scientific Reports, 2022 - nature.com
The essential role of gut microbiota in health and disease is well recognized, but the
biochemical details that underlie the beneficial impact remain largely undefined. To maintain …