Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

Alkylating agents have been used since the 60ties in brain cancer chemotherapy. Their
target is the DNA and, although the DNA of normal and cancer cells is damaged …

Steroid hormone signaling induces vast gene expression programs which necessitate the
local formation of transcription factories at regulatory regions and large-scale alterations of …

Poly (ADP-ribose) polymerase (PARP) inhibitors are a therapeutic milestone exerting a
synthetic lethal effect in the treatment of cancer involving BRCA1/2 mutation. Theoretically …

Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

The genotoxic methylating agents temozolomide (TMZ) and procarbazine and the
chloroethylating nitrosourea lomustine (CCNU) are part of the standard repertoire in the …

The critical role of dysregulated epigenetic pathways in cancer genesis, development, and
therapy has typically been established as a result of scientific and technical innovations in …

Upon the induction of DNA damage, the chromatin structure unwinds to allow access to
enzymes to catalyse the repair. The regulation of the winding and unwinding of chromatin …

Introduction Variants in the tau gene (MAPT) region are associated with breast cancer in
women and Alzheimer's disease (AD) among persons lacking apolipoprotein E ε4 (ε4–) …

Temozolomide (TMZ) is the most preferred and approved chemotherapeutic drug for either
first-or second-line chemotherapy for glioma patients across the globe. In glioma patients …