Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …

CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …

Vaccination affords protection from disease by activating pathogen-specific immune cells
and facilitating the development of persistent immunologic memory toward the vaccine …

Cytotoxic T cell immunity in response to chronic infections and tumours is maintained by a
specialized population of CD8+ T cells that exhibit hallmarks of both exhausted and memory …

Chimeric antigen receptor (CAR) costimulatory domains derived from native immune
receptors steer the phenotypic output of therapeutic T cells. We constructed a library of …

Antiretroviral therapies efficiently block HIV-1 replication but need to be maintained for life.
Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite …

One of the hallmarks of the vertebrate adaptive immune system is the prolific expansion of
individual cell clones that encounter their cognate antigen. More recently, however, there is …

Synthetic antigen-presenting cells (APCs) are used to mediate scalable ex vivo T-cell
expansion for adoptive cell therapy. Recently, we developed APC-mimetic scaffolds (APC …

A hallmark of chronic infections is the presence of exhausted CD8 T cells, characterized by a
distinct transcriptional program compared with functional effector or memory cells, co …

T cells play important roles in autoimmune diseases and cancer. Following the cloning of the
T cell receptor (TCR), the race was on to map signaling proteins that contributed to T cell …