Pathogenesis of type 2 diabetes mellitus (T2DM) and development of insulin resistance are
characterized by multi‐stimuli factors notably glucolipotoxicity, generation of reactive oxygen …

Despite recent medical advances, atherosclerosis is a global burden accounting for
numerous deaths and hospital admissions. Immune-mediated inflammation is a major …

Background: Diet may be associated with the development of type 2 diabetes through its
effects on low-grade inflammation. Objectives: We investigated whether an adapted dietary …

Abstract Background The German Diabetes Study (GDS) is a prospective longitudinal cohort
study describing the impact of subphenotypes on the course of the disease. GDS aims at …

The complement system has been implicated in obesity, fatty liver, diabetes and
cardiovascular disease (CVD). Complement factors are produced in adipose tissue and …

Background & aims Short bouts of severe energy restriction may have additional, beneficial
cardiometabolic effects beyond that of weight loss. We aimed to assess the short-term effects …

As the common factor linking adipose tissue to the metabolic context of obesity, insulin
resistance and atherosclerosis are associated with a low-grade chronic inflammatory status …

OBJECTIVE Immune dysregulation can affect insulin resistance (IR) and β-cell function and
hence contribute to development of type 2 diabetes mellitus (T2DM). The complement …

Multiple myeloma (MM) is an incurable hematologic malignancy. Most MM patients are
diagnosed at a late stage because the early symptoms of the disease can be uncertain and …

We are currently experiencing an enduring global epidemic of obesity and diabetes. It is
now understood that chronic low-grade tissue inflammation plays an important role in …