The glymphatic system: Current understanding and modeling
We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …
Waste clearance in the brain
J Kaur, LM Fahmy, E Davoodi-Bojd, L Zhang… - Frontiers in …, 2021 - frontiersin.org
Waste clearance (WC) is an essential process for brain homeostasis, which is required for
the proper and healthy functioning of all cerebrovascular and parenchymal brain cells. This …
the proper and healthy functioning of all cerebrovascular and parenchymal brain cells. This …
Impaired glymphatic transport in spontaneously hypertensive rats
The glymphatic system is a brainwide CSF transport system that uses the perivascular space
for fast inflow of CSF. Arterial pulsations are a major driver of glymphatic CSF inflow, and …
for fast inflow of CSF. Arterial pulsations are a major driver of glymphatic CSF inflow, and …
Optimal mass transport with lagrangian workflow reveals advective and diffusion driven solute transport in the glymphatic system
The glymphatic system (GS) hypothesis states that advective driven cerebrospinal fluid
(CSF) influx from the perivascular spaces into the interstitial fluid space rapidly transport …
(CSF) influx from the perivascular spaces into the interstitial fluid space rapidly transport …
A real-time in vivo clearance assay for quantification of glymphatic efflux
Glymphatic fluid transport eliminates metabolic waste from the brain including amyloid-β, yet
the methodology for studying efflux remains rudimentary. Here, we develop a method to …
the methodology for studying efflux remains rudimentary. Here, we develop a method to …
Noninvasive characterization of human glymphatics and meningeal lymphatics in an in vivo model of blood–brain barrier leakage
Objective To evaluate human glymphatics and meningeal lymphatics noninvasively.
Methods This prospective study implemented 3‐dimensional (3D) isotropic contrast …
Methods This prospective study implemented 3‐dimensional (3D) isotropic contrast …
Glymphatic cerebrospinal fluid and solute transport quantified by MRI and PET imaging
Over the past decade there has been an enormous progress in our understanding of fluid
and solute transport in the central nervous system (CNS). This is due to a number of factors …
and solute transport in the central nervous system (CNS). This is due to a number of factors …
Neurons, glia, extracellular matrix and neurovascular unit: a systems biology approach to the complexity of synaptic plasticity in health and disease
C De Luca, AM Colangelo, A Virtuoso… - International journal of …, 2020 - mdpi.com
The synaptic cleft has been vastly investigated in the last decades, leading to a novel and
fascinating model of the functional and structural modifications linked to synaptic …
fascinating model of the functional and structural modifications linked to synaptic …
[HTML][HTML] Neuroimaging at 7 Tesla: a pictorial narrative review
T Okada, K Fujimoto, Y Fushimi, T Akasaka… - … imaging in medicine …, 2022 - ncbi.nlm.nih.gov
Abstract Neuroimaging using the 7-Tesla (7T) human magnetic resonance (MR) system is
rapidly gaining popularity after being approved for clinical use in the European Union and …
rapidly gaining popularity after being approved for clinical use in the European Union and …
Cerebral microcirculation, perivascular unit, and glymphatic system: role of aquaporin-4 as the gatekeeper for water homeostasis
J Szczygielski, M Kopańska, A Wysocka… - Frontiers in …, 2021 - frontiersin.org
In the past, water homeostasis of the brain was understood as a certain quantitative
equilibrium of water content between intravascular, interstitial, and intracellular spaces …
equilibrium of water content between intravascular, interstitial, and intracellular spaces …