Nanotherapeutics for pulmonary drug delivery: An emerging approach to overcome respiratory diseases

E Kole, K Jadhav, N Shirsath, P Dudhe… - Journal of Drug Delivery …, 2023 - Elsevier
Pulmonary diseases pose an immense threat to global health. Several nanotherapeutics-
based approaches aimed to tackle pulmonary ailments in recent years. The current …

Inhaled drug delivery for the targeted treatment of asthma

A Boboltz, S Kumar, GA Duncan - Advanced Drug Delivery Reviews, 2023 - Elsevier
Asthma is a chronic lung disease affecting millions worldwide. While classically
acknowledged to result from allergen-driven type 2 inflammatory responses leading to IgE …

Real‐Time Measurement of Cell Mechanics as a Clinically Relevant Readout of an In Vitro Lung Fibrosis Model Established on a Bioinspired Basement Membrane

A Doryab, MB Taskin, P Stahlhut, J Groll… - Advanced …, 2022 - Wiley Online Library
Lung fibrosis, one of the major post‐COVID complications, is a progressive and ultimately
fatal disease without a cure. Here, an organ‐and disease‐specific in vitro mini‐lung fibrosis …

Biomimetic in vitro lung models: current challenges and future perspective

A Doryab, J Groll - Advanced Materials, 2023 - Wiley Online Library
As post‐COVID complications, chronic respiratory diseases are one of the foremost causes
of mortality. The quest for a cure for this recent global challenge underlines that the lack of …

Engineering in vitro models of cystic fibrosis lung disease using neutrophil extracellular trap inspired biomaterials

A Boboltz, S Yang, GA Duncan - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
Cystic fibrosis (CF) is a muco-obstructive lung disease where inflammatory responses due to
chronic infection result in the accumulation of neutrophil extracellular traps (NETs) in the …

[HTML][HTML] Recent options and techniques to assess improved bioavailability: In vitro and ex vivo methods

L Józsa, D Nemes, Á Pető, D Kósa, R Révész… - Pharmaceutics, 2023 - mdpi.com
Bioavailability assessment in the development phase of a drug product is vital to reveal the
disadvantageous properties of the substance and the possible technological interventions …

[HTML][HTML] Human lung cell models to study aerosol delivery–Considerations for model design and development

B Rothen-Rutishauser, M Gibb, R He… - European Journal of …, 2023 - Elsevier
Human lung tissue models range from simple monolayer cultures to more advanced three-
dimensional co-cultures. Each model system can address the interactions of different types …

[HTML][HTML] Trends in 3D models of inflammatory bowel disease

B Ferreira, AS Barros, C Leite-Pereira, J Viegas… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Inflammatory bowel disease (IBD) encompasses a set of chronic inflammatory conditions,
namely Crohn's disease and ulcerative colitis. Despite all advances in the management of …

Performance of nanoparticles for biomedical applications: The in vitro/in vivo discrepancy

S Berger, M Berger, C Bantz, M Maskos… - Biophysics Reviews, 2022 - pubs.aip.org
Nanomedicine has a great potential to revolutionize the therapeutic landscape. However, up-
to-date results obtained from in vitro experiments predict the in vivo performance of …

[HTML][HTML] In vitro dissolution and permeability testing of inhalation products: Challenges and advances

A Nokhodchi, S Chavan, T Ghafourian - Pharmaceutics, 2023 - mdpi.com
In vitro dissolution and permeability testing aid the simulation of the in vivo behavior of
inhalation drug products. Although the regulatory bodies have specific guidelines for the …