Nanotherapeutics for pulmonary drug delivery: An emerging approach to overcome respiratory diseases
Pulmonary diseases pose an immense threat to global health. Several nanotherapeutics-
based approaches aimed to tackle pulmonary ailments in recent years. The current …
based approaches aimed to tackle pulmonary ailments in recent years. The current …
Inhaled drug delivery for the targeted treatment of asthma
Asthma is a chronic lung disease affecting millions worldwide. While classically
acknowledged to result from allergen-driven type 2 inflammatory responses leading to IgE …
acknowledged to result from allergen-driven type 2 inflammatory responses leading to IgE …
Real‐Time Measurement of Cell Mechanics as a Clinically Relevant Readout of an In Vitro Lung Fibrosis Model Established on a Bioinspired Basement Membrane
Lung fibrosis, one of the major post‐COVID complications, is a progressive and ultimately
fatal disease without a cure. Here, an organ‐and disease‐specific in vitro mini‐lung fibrosis …
fatal disease without a cure. Here, an organ‐and disease‐specific in vitro mini‐lung fibrosis …
Biomimetic in vitro lung models: current challenges and future perspective
As post‐COVID complications, chronic respiratory diseases are one of the foremost causes
of mortality. The quest for a cure for this recent global challenge underlines that the lack of …
of mortality. The quest for a cure for this recent global challenge underlines that the lack of …
Engineering in vitro models of cystic fibrosis lung disease using neutrophil extracellular trap inspired biomaterials
Cystic fibrosis (CF) is a muco-obstructive lung disease where inflammatory responses due to
chronic infection result in the accumulation of neutrophil extracellular traps (NETs) in the …
chronic infection result in the accumulation of neutrophil extracellular traps (NETs) in the …
[HTML][HTML] Recent options and techniques to assess improved bioavailability: In vitro and ex vivo methods
Bioavailability assessment in the development phase of a drug product is vital to reveal the
disadvantageous properties of the substance and the possible technological interventions …
disadvantageous properties of the substance and the possible technological interventions …
[HTML][HTML] Human lung cell models to study aerosol delivery–Considerations for model design and development
B Rothen-Rutishauser, M Gibb, R He… - European Journal of …, 2023 - Elsevier
Human lung tissue models range from simple monolayer cultures to more advanced three-
dimensional co-cultures. Each model system can address the interactions of different types …
dimensional co-cultures. Each model system can address the interactions of different types …
[HTML][HTML] Trends in 3D models of inflammatory bowel disease
B Ferreira, AS Barros, C Leite-Pereira, J Viegas… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Inflammatory bowel disease (IBD) encompasses a set of chronic inflammatory conditions,
namely Crohn's disease and ulcerative colitis. Despite all advances in the management of …
namely Crohn's disease and ulcerative colitis. Despite all advances in the management of …
Performance of nanoparticles for biomedical applications: The in vitro/in vivo discrepancy
S Berger, M Berger, C Bantz, M Maskos… - Biophysics Reviews, 2022 - pubs.aip.org
Nanomedicine has a great potential to revolutionize the therapeutic landscape. However, up-
to-date results obtained from in vitro experiments predict the in vivo performance of …
to-date results obtained from in vitro experiments predict the in vivo performance of …
[HTML][HTML] In vitro dissolution and permeability testing of inhalation products: Challenges and advances
A Nokhodchi, S Chavan, T Ghafourian - Pharmaceutics, 2023 - mdpi.com
In vitro dissolution and permeability testing aid the simulation of the in vivo behavior of
inhalation drug products. Although the regulatory bodies have specific guidelines for the …
inhalation drug products. Although the regulatory bodies have specific guidelines for the …