Although most animal cells contain centrosomes, consisting of a pair of centrioles, their
precise contribution to cell division and embryonic development is unclear. Genetic ablation …

Cell division and differentiation are two fundamental physiological processes that need to be
tightly balanced to achieve harmonious development of an organ or a tissue without …

More than 80% of malignant tumors show centrosome amplification and clustering.
Centrosome amplification results from aberrations in the centrosome duplication cycle …

CHFR (Checkpoint with Forkhead-associated and RING finger domains) has been
implicated in a checkpoint regulating entry into mitosis. However, the details underlying its …

The STIL protein is essential for centriole replication and for the non-templated, de novo
centriole biogenesis that is required for mammalian embryogenesis. Here we performed …

Abstract STIL (SCL/TAL1 interrupting locus) is a core component of the centriole duplication
process. STIL mutations have been associated with both autosomal recessive primary …

Protein-protein interactions mediate most of the processes in the living cell and control
homeostasis of the organism. Impaired protein interactions may result in disease, making …

Coiled-coil domains (CCDs) play key roles in regulating both healthy cellular processes and
the pathogenesis of various diseases by controlling protein self-association and protein …

Advanced ovarian cancer is an incurable disease. Thus, novel therapies are required. We
wished to identify new therapeutic targets for ovarian cancer. ShRNA screen performed in …

Outbreaks of porcine epidemic diarrhea virus (PEDV) have caused significant lethality rates
in neonatal piglets, which pose a serious threat to the swine industry worldwide. Available …