The JAK/STAT signaling pathway: from bench to clinic
X Hu, J Li, M Fu, X Zhao, W Wang - Signal transduction and targeted …, 2021 - nature.com
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
Targeting STAT3 in cancer immunotherapy
S Zou, Q Tong, B Liu, W Huang, Y Tian, X Fu - Molecular cancer, 2020 - Springer
As a point of convergence for numerous oncogenic signaling pathways, signal transducer
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …
[HTML][HTML] Mechanisms of temozolomide resistance in glioblastoma-a comprehensive review
N Singh, A Miner, L Hennis, S Mittal - Cancer drug resistance, 2021 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an
exceedingly low median overall survival of only 15 months. Current standard-of-care for …
exceedingly low median overall survival of only 15 months. Current standard-of-care for …
PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production
LJ Celada, JA Kropski, JD Herazo-Maya… - Science translational …, 2018 - science.org
Pulmonary fibrosis is a progressive inflammatory disease with high mortality and limited
therapeutic options. Previous genetic and immunologic investigations suggest common …
therapeutic options. Previous genetic and immunologic investigations suggest common …
Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response
S Hombach-Klonisch, M Mehrpour, S Shojaei… - Pharmacology & …, 2018 - Elsevier
Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …
ERK1/2 MAP kinases in cell survival and apoptosis
Z Lu, S Xu - IUBMB life, 2006 - Wiley Online Library
ERK1/2 is an important subfamily of mitogen‐activated protein kinases that control a broad
range of cellular activities and physiological processes. ERK1/2 can be activated transiently …
range of cellular activities and physiological processes. ERK1/2 can be activated transiently …
STAT3 activation: A key factor in tumor immunoescape
Cancer growth is controlled by cancer cells (cell intrinsic phenomenon), but also by the
immune cells in the tumor microenvironment (cell extrinsic phenomenon). Thus cancer …
immune cells in the tumor microenvironment (cell extrinsic phenomenon). Thus cancer …
CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice
Immune mechanisms are known to control the pathogenesis of atherosclerosis. However,
the exact role of DCs, which are essential for priming of immune responses, remains elusive …
the exact role of DCs, which are essential for priming of immune responses, remains elusive …
Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
N De La Iglesia, G Konopka, SV Puram… - Genes & …, 2008 - genesdev.cshlp.org
Activation of the transcription factor STAT3 is thought to potently promote oncogenesis in a
variety of tissues, leading to intense efforts to develop STAT3 inhibitors for many tumors …
variety of tissues, leading to intense efforts to develop STAT3 inhibitors for many tumors …
Mutant V599EB-Raf Regulates Growth and Vascular Development of Malignant Melanoma Tumors
A Sharma, NR Trivedi, MA Zimmerman, DA Tuveson… - Cancer research, 2005 - AACR
Activating mutations of the B-RAF gene are observed in> 60% of human melanomas.
Approximately 90% of these mutations occur in the activation segment of the kinase domain …
Approximately 90% of these mutations occur in the activation segment of the kinase domain …