Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …

The COVID-19 pandemic caused by the coronavirus (SARS-CoV-2) has taken the world by
surprise into a major crisis of overwhelming morbidity and mortality. This highly infectious …

Reactive oxygen species (ROS) mediate lipid peroxidation and produce 4-hydroxynonenal
and other related products, which play an important role in the process of cell death …

Mitochondria are highly plastic and dynamic organelles that have graded responses to the
changing cellular, environmental, and developmental cues. Mitochondria undergo constant …

Metals are involved in different pathophysiological mechanisms associated with
neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's …

Iron is a critical component of many cellular functions including DNA replication and repair,
and it is essential for cell vitality. As an essential element, iron is critical for maintaining …

Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism
must be tightly controlled within cells. Whilst fundamental to many cellular processes and …

Iron is an essential micronutrient for a myriad of physiological processes in the body beyond
erythropoiesis. Iron deficiency (ID) is a common comorbidity in patients with heart failure …

Osteoporosis can be caused by a multitude of factors and is defined by a decrease in bone
density and mass caused by the destruction of bone microstructure, resulting in increased …

Acetaminophen (APAP) overdose is a common cause of drug-induced liver injury (DILI).
Ferroptosis has been recently implicated in APAP-induced liver injury (AILI). However, the …