Background Several recent observational studies have reported that gut microbiota
composition is associated with preeclampsia. However, the causal effect of gut microbiota …

Background Recent studies have indicated a potential correlation between intestinal
bacteria and primary ovarian insufficiency (POI). However, the causal relationship between …

Background Accumulating evidence has indicated that persistent human cytomegalovirus
(HCMV) infection is associated with several cardiovascular diseases including …

Background Obesity, especially abdominal obesity, is an independent indicator of increased
cardiovascular risk. Observational studies have shown an observational association …

Background Recent studies have suggested a potential link between systemic inflammatory
regulators and primary ovarian insufficiency (POI); however, a causal relationship between …

Objective Investigating the causal relationship between rheumatoid arthritis (RA) and
atlantoaxial subluxation (AAS) and identifying and quantifying the role of C-reactive protein …

Background Atrial fibrillation (AF) is the most common and persistent form of arrhythmia.
Recently, increasing evidence has shown a link between immune responses and atrial …

Aims This study aimed to evaluate the causal association between obesity and hypertension
disorders in pregnancy. Methods Two-sample Mendelian randomization (MR) study was …

Objective To investigate the link between genetic variants associated with plasma
homocysteine levels and risk of intracranial aneurysm (IA) using two-sample Mendelian …

Background Despite numerous observational studies, the causal relationship between
obesity—measured by body mass index (BMI) and waist circumference (WC)—as well as …