Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains
the main characteristics of biological membranes, such as lipid bilayer, but differs from them …

In the central nervous system (CNS) of most vertebrates, oligodendrocytes enwrap neuronal
axons with extensions of their plasma membrane to form the myelin sheath. Several proteins …

Amyotrophic lateral sclerosis–frontotemporal dementia (ALS-FTD) constitutes a devastating
disease spectrum characterized by 43-kDa TAR DNA-binding protein (TDP-43) pathology …

Radiation therapy to the brain is a powerful tool in the management of many cancers, but it is
associated with significant and irreversible long-term side effects, including cognitive decline …

In the enteric nervous system (ENS), glia outnumber neurons by 4‐fold and form an
extensive network throughout the gastrointestinal tract. Growing evidence for the essential …

The regenerative capacity of peripheral nerves declines during aging, contributing to the
development of neuropathies, limiting organism function. Changes in Schwann cells prompt …

The classic isoforms of myelin basic protein (MBP, 14–21.5 kDa) are essential to formation
of the multilamellar myelin sheath of the mammalian central nervous system (CNS). The …

Alzheimer´ s disease (AD) is characterized by a progressive cognitive decline that correlates
with the levels of amyloid β-peptide (Aβ) oligomers. Strong evidences connect changes of …

Blood-based biomarkers for traumatic brain injury (TBI) have been investigated and
proposed for decades, yet the current clinical assessment of TBI is largely based on clinical …

Brain injuries in multiple sclerosis (MS) involve immunopathological, structural and
metabolic defects on myelin sheath, oligodendrocytes (OLs), axons and neurons suggesting …