Primary aldosteronism is characterized by aldosterone secretion that is independent of renin
and angiotensin II and sodium status. The deleterious effects of primary aldosteronism are …

We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

Primary aldosteronism (PA) represents the most common cause of secondary hypertension,
but little is known regarding its adrenal cellular origins. Recently, aldosterone-producing cell …

Primary aldosteronism is the most common form of secondary hypertension. Somatic
mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D have been described in aldosterone …

Hypertension is one of the major risk factors of cardiovascular diseases, but despite a
century of clinical and basic research, the discrete etiology of this disease is still not fully …

Primary aldosteronism is considered the commonest cause of secondary hypertension. In
affected individuals, aldosterone is produced in an at least partially autonomous fashion in …

In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …

Primary aldosteronism (PA) is the most common form of endocrine hypertension and is
characterized by inappropriately elevated aldosterone production via a renin-independent …

Primary aldosteronism comprises 2 main subtypes: unilateral aldosterone-producing
adenoma (APA) and bilateral adrenal hyperplasia. Somatic KCNJ5 mutations are found in …

Background Aldosterone producing lesions are a common cause of hypertension, but
genetic alterations for tumorigenesis have been unclear. Recently, either of two recurrent …