Cisplatin is a widely used chemotherapeutic agent used to treat solid tumours, such as
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …

Traumatic brain injury (TBI) presents in various forms ranging from mild alterations of
consciousness to an unrelenting comatose state and death. In the most severe form of TBI …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Cell-to-cell communication can be inferred from ligand–receptor expression in cell
transcriptomic datasets. However, important challenges remain: global integration of cell-to …

The cytokine erythropoietin (Epo) is tissue-protective in preclinical models of ischemic,
traumatic, toxic, and inflammatory injuries. We have recently characterized Epo derivatives …

Cerebral malaria (CM) caused by Plasmodium falciparum is a fatal neurological
complication of malaria, resulting in coma and death, and even survivors may suffer long …

In recent years, much interest has been devoted to defining the role of the IGF system in the
nervous system. The ubiquitous IGFs, their cell membrane receptors, and their carrier …

Publisher Summary This chapter highlights the controversies concerning the role of brain
inflammation elicited after brain trauma. In clinical practice, classification of primary brain …

Erythropoietin mediates an evolutionarily conserved, ancient immune response that limits
damage to the heart, the nervous system and other tissues following injury. New evidence …