Ferroptosis is a non‐apoptotic programmed cell death caused by the accumulation of lipid
peroxide. System Xc‐/glutathione peroxidase 4 (GPX4) axis and iron axis are two main …

Apoptosis is a programmed cell death comprising two signaling cascades including the
intrinsic and extrinsic pathways. This process has been shown to be involved in the therapy …

Ethnopharmacological relevance Traditional medicinal plants have gained attention as a
potential therapeutic agent to combat cancer and inflammation. Diosgenin rich fresh extracts …

Piperlongumine (PL, piplartine) is an alkaloid derived from the Piper longum L.(long pepper)
roots. Originally discovered in 1961, the biological activities of this molecule against some …

Cervical cancer is the most prevalent cancer in females. Melatonin, a neurohormone has
been documented as a promising therapeutic molecule for cervical cancer. However, the …

Simple Summary Scabertopin is one of the major sesquiterpene lactones from
Elephantopus scaber L. Sesquiterpene lactones are thought to have fairly strong anti-cancer …

Cancer is a leading cause of morbidity and mortality worldwide. The development of cancer
involves aberrations in multiple pathways, representing promising targets for anti-cancer …

Metastasis is a multi-step phenomenon during cancer development leading to the
propagation of cancer cells to distant organ (s). According to estimations, metastasis results …

Several bioactive compounds are in use for the treatment of neurodegenerative disorders,
such as Alzheimer's and Parkinson's disease. Historically, willow (salix sp.) bark has been …

Scabertopin (SCP), an abundant germacrane-type sesquiterpene lactone (SLC) isolated
from Elephantopus scaber, was selected as a reference compound for modification and …