All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms
develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …

Lamins are nuclear intermediate filament proteins with important, well-established roles in
humans and other vertebrates. Lamins interact with DNA and numerous proteins at the …

Nesprins (nuclear envelope spectrin repeat proteins) are multi-isomeric scaffolding proteins.
Giant nesprin-1 and-2 localise to the outer nuclear membrane, interact with SUN …

Striated muscle laminopathies caused by missense mutations in the nuclear lamin gene
LMNA are characterized by cardiac dysfunction and often skeletal muscle defects. Attempts …

Dilated cardiomyopathy caused by mutations in LMNA, encoding A-type lamins (ie, LMNA
cardiomyopathy), is characterized by a left ventricle enlargement and ultimately results in …

The nuclear lamina (NL) plays various roles and participates in nuclear integrity, chromatin
organization, and transcriptional regulation. Lamin proteins, the main components of the NL …

The contractile cells of skeletal muscles, called myofibers, are elongated multinucleated
syncytia formed and maintained by the fusion of proliferative myoblasts. Human myofibers …

Mutations in the LMNA gene-encoding A-type lamins can cause Limb–Girdle muscular
dystrophy Type 1B (LGMD1B). This disease presents with weakness and wasting of the …

Mutations in the LMNA gene cause a collection of diseases known as laminopathies,
including muscular dystrophies, lipodystrophies, and early-onset aging syndromes. The …

Mutations in the LMNA gene cause a collection of diseases known as laminopathies,
including muscular dystrophies, lipodystrophies, and early-onset aging syndromes. The …