Anthracyclines: biosynthesis, engineering and clinical applications
MB Hulst, T Grocholski, JJC Neefjes… - Natural Product …, 2022 - pubs.rsc.org
Covering: January 1995 to June 2021 Anthracyclines are glycosylated microbial natural
products that harbour potent antiproliferative activities. Doxorubicin has been widely used as …
products that harbour potent antiproliferative activities. Doxorubicin has been widely used as …
[HTML][HTML] Antimicrobial resistance in biofilms: Exploring marine actinobacteria as a potential source of antibiotics and biofilm inhibitors
Antimicrobial resistance (AMR) is one of the serious global public health threats that require
immediate action. With the emergence of new resistance mechanisms in infection-causing …
immediate action. With the emergence of new resistance mechanisms in infection-causing …
Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes
Bacterial specialized metabolites are a proven source of antibiotics and cancer therapies,
but whether we have sampled all the secondary metabolite chemical diversity of cultivated …
but whether we have sampled all the secondary metabolite chemical diversity of cultivated …
Soil biodiversity supports the delivery of multiple ecosystem functions in urban greenspaces
While the contribution of biodiversity to supporting multiple ecosystem functions is well
established in natural ecosystems, the relationship of the above-and below-ground diversity …
established in natural ecosystems, the relationship of the above-and below-ground diversity …
[HTML][HTML] Important ecophysiological roles of non-dominant Actinobacteria in plant residue decomposition, especially in less fertile soils
Background Microbial-driven decomposition of plant residues is integral to carbon
sequestration in terrestrial ecosystems. Actinobacteria, one of the most widely distributed …
sequestration in terrestrial ecosystems. Actinobacteria, one of the most widely distributed …
[HTML][HTML] A genomic catalogue of soil microbiomes boosts mining of biodiversity and genetic resources
Soil harbors a vast expanse of unidentified microbes, termed as microbial dark matter,
presenting an untapped reservoir of microbial biodiversity and genetic resources, but has …
presenting an untapped reservoir of microbial biodiversity and genetic resources, but has …
Extreme summers impact cropland and grassland soil microbiomes
Q Bei, T Reitz, B Schnabel, N Eisenhauer… - The ISME …, 2023 - academic.oup.com
The increasing frequency of extreme weather events highlights the need to understand how
soil microbiomes respond to such disturbances. Here, metagenomics was used to …
soil microbiomes respond to such disturbances. Here, metagenomics was used to …
Plant microbiomes harbor potential to promote nutrient turnover in impoverished substrates of a Brazilian biodiversity hotspot
The substrates of the Brazilian campos rupestre s, a grassland ecosystem, have extremely
low concentrations of phosphorus and nitrogen, imposing restrictions to plant growth …
low concentrations of phosphorus and nitrogen, imposing restrictions to plant growth …
[HTML][HTML] Biosynthetic gene cluster profiling predicts the positive association between antagonism and phylogeny in Bacillus
L Xia, Y Miao, A Cao, Y Liu, Z Liu, X Sun, Y Xue… - Nature …, 2022 - nature.com
Understanding the driving forces and intrinsic mechanisms of microbial competition is a
fundamental question in microbial ecology. Despite the well-established negative …
fundamental question in microbial ecology. Despite the well-established negative …
[HTML][HTML] Streptomyces polyketides mediate bacteria–fungi interactions across soil environments
MKC Krespach, MC Stroe, T Netzker, M Rosin… - Nature …, 2023 - nature.com
Although the interaction between prokaryotic and eukaryotic microorganisms is crucial for
the functioning of ecosystems, information about the processes driving microbial interactions …
the functioning of ecosystems, information about the processes driving microbial interactions …