Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …

Ketamine is a phencyclidine derivative, which functions primarily as an antagonist of the N-
methyl-d-aspartate receptor. It has no affinity for gamma-aminobutyric acid receptors in the …

Ketamine is a noncompetitive antagonist of N-methyl-d-asparate (NMDA) receptor and has
been long used as an anesthetic agent in humans and veterinary medicine. The present …

Introduction Ketamine can produce rapid-acting antidepressant effects. Esketamine
(Spravato), the S-enantiomer of racemic ketamine, was approved by the FDA for treatment …

Hallucinogens fall into several different classes, as broadly defined by pharmacological
mechanism of action, and chemical structure. These include psychedelics, entactogens …

Ketamine was discovered in the 1960s and released for public use in 1970. Originally
developed as a safer alternative to phencyclidine, ketamine is primarily used in clinical …

Ketamine, a molecule of many faces, has contributed immeasurably to numerous realms of
clinical practice and scientific inquiry. From anesthesia and analgesia to depression and …

Over the last two decades, the dissociative anaesthetic agent ketamine, an uncompetitive N-
Methyl-D-Aspartate (NMDA) receptor antagonist, has emerged as a novel therapy for …

Background Depressed patients presenting to emergency departments with acute suicidal
ideation are a major public health concern. Ketamine, a rapidly acting antidepressant with …

Background Opioids are commonly prescribed in the emergency department (ED) for the
treatment of acute pain. Analgesic alternatives are being explored in response to an …