Biotransformations and biological activities of hop flavonoids

M Karabin, T Hudcova, L Jelinek, P Dostalek - Biotechnology advances, 2015 - Elsevier
Female hop cones are used extensively in the brewing industry, but there is now increasing
interest in possible uses of hops for non-brewing purposes, especially in the pharmaceutical …

Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

J Robert, EB Button, B Yuen, M Gilmour, K Kang… - Elife, 2017 - elifesciences.org
Amyloid plaques, consisting of deposited beta-amyloid (Aβ), are a neuropathological
hallmark of Alzheimer's Disease (AD). Cerebral vessels play a major role in AD, as Aβ is …

The glymphatic system: a new perspective on brain diseases

Z Ding, X Fan, Y Zhang, M Yao, G Wang… - Frontiers in Aging …, 2023 - frontiersin.org
The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the
endfeet of astrocytes, which can deliver nutrients and active substances to the brain …

Impact on the brain of the inflammatory response to surgery

S Saxena, M Maze - La Presse Médicale, 2018 - Elsevier
The brain is both the orchestrator as well as the target of the innate immune system's
response to the aseptic trauma of surgery. When trauma-induced inflammation is not …

Drug delivery strategies to enhance the permeability of the blood–brain barrier for treatment of glioma

F Zhang, CL Xu, CM Liu - Drug Design, Development and Therapy, 2015 - Taylor & Francis
Gliomas are amongst the most insidious and destructive types of brain cancer and are
associated with a poor prognosis, frequent recurrences, and extremely high lethality despite …

[HTML][HTML] Systemic delivery to central nervous system by engineered PLGA nanoparticles

Q Cai, L Wang, G Deng, J Liu, Q Chen… - American journal of …, 2016 - ncbi.nlm.nih.gov
Neurological disorders are an important global public health problem, but pharmaceutical
treatments are limited due to drug access to the central nervous system being restricted by …

Electrotherapies for glioblastoma

EPW Jenkins, A Finch, M Gerigk, IF Triantis… - Advanced …, 2021 - Wiley Online Library
Abstract Non‐thermal, intermediate frequency (100–500 kHz) electrotherapies present a
unique therapeutic strategy to treat malignant neoplasms. Here, pulsed electric fields (PEFs) …

[HTML][HTML] Chemical profiles and pharmacological insights of Anisomeles indica Kuntze: An experimental chemico-biological interaction

S Nasrin, MN Islam, MA Tayab, MS Nasrin… - Biomedicine & …, 2022 - Elsevier
Anisomeles indica (L.) Kuntze is an ethnomedicinally important plant that has long been
used in traditional medicine to treat a variety of ailments, including dyspepsia, abdominal …

Adenosine receptor signaling: a key to opening the blood–brain door

MS Bynoe, C Viret, A Yan, DG Kim - Fluids and Barriers of the CNS, 2015 - Springer
The aim of this review is to outline evidence that adenosine receptor (AR) activation can
modulate blood–brain barrier (BBB) permeability and the implications for disease states and …

[HTML][HTML] In vitro biomimetic models for glioblastoma-a promising tool for drug response studies

T Stanković, T Ranđelović, M Dragoj, SS Burić… - Drug Resistance …, 2021 - Elsevier
The poor response of glioblastoma to current treatment protocols is a consequence of its
intrinsic drug resistance. Resistance to chemotherapy is primarily associated with …