The blood-brain barrier accounts for the high attrition rate of the treatments of most brain
disorders, which therefore remain one of the greatest health-care challenges of the twenty …

Primary cell isolation from the central nervous system (CNS) has allowed fundamental
understanding of blood-brain barrier (BBB) properties. However, poorly described isolation …

Lipids are the most abundant organic compounds found in the brain, accounting for up to
50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical …

Traditional experimental approaches to evaluate the Blood-Brain Barrier (BBB) permeability
of a drug are expensive and time consuming. Hence, several computational models have …

The blood-brain barrier (BBB) functions as a highly selective border of endothelial cells,
protecting the central nervous system from potentially harmful substances by selectively …

The human blood–brain barrier (BBB) represents the interface of microvasculature and the
central nervous system, regulating the transport of nutrients and protecting the brain from …

Selegiline hydrochloride (SL), is an anti-Parkinson's agent, has low-oral bioavailability due
to its high first pass metabolism and scarce oral absorption. In the present study, SL …

Neurodegenerative disorders are a major public health issue. Despite decades of research
efforts, we are still seeking an efficient cure for these pathologies. The initial paradigm of …

Despite the enormous research efforts that have been put into the development of central
nervous system (CNS) drugs, the success rate in this area is still disappointing. To increase …

The determination of the permeability of drug candidates across the blood–brain barrier
(BBB) is a fundamental step during drug discovery programs. The parallel artificial …