Frontotemporal dementia (FTD) is a neurodegenerative disease, leading to behavioral
changes and language difficulties. Heterozygous loss-of-function mutations in progranulin …

Neurodegenerative diseases such as Alzheimer's disease have proven resistant to new
treatments. The complexity of neurodegenerative disease mechanisms can be highlighted …

Heterozygous loss-of-function mutations in progranulin (GRN) cause frontotemporal
dementia (FTD), a leading cause of early-onset dementia characterized clinically by …

Progranulin (PGRN), encoded by the GRN gene in humans, was originally isolated as a
secreted growth factor that implicates in a multitude of processes ranging from regulation of …

Progranulin (PGRN) is a protein encoded by the GRN gene with multiple identified functions
including as a neurotrophic factor, tumorigenic growth factor, anti-inflammatory cytokine and …

Background Blood–spinal cord barrier (BSCB) disruption is a key event after spinal cord
injury (SCI), which permits unfavorable blood-derived substances to enter the neural tissue …

Neuroimmune dysfunction is a cardinal feature of neurodegenerative diseases. But how
immune dysregulation in the brain and peripheral organs contribute to neurodegeneration …

Immunoproteostasis is a term used to reflect interactions between the immune system and
the proteinopathies that are presumptive" triggers" of many neurodegenerative disorders …

Genetic variants in Granulin (GRN), which encodes the secreted glycoprotein progranulin
(PGRN), are associated with several neurodegenerative diseases, including frontotemporal …

Background Alterations in progranulin (PGRN) expression are associated with multiple
neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer's …