Background The processes of DNA supercoiling and transcription are interdependent
because the movement of a transcription elongation complex simultaneously induces under …

Since the discovery of the Escherichia coli leucine-responsive regulatory protein (Lrp)
almost 50 years ago, hundreds of Lrp homologs have been discovered, occurring in 45% of …

Mutually beneficial interactions are ubiquitous in nature and have played a pivotal role for
the evolution of life on earth. However, the factors facilitating their emergence remain poorly …

Broad-acting transcription factors (TFs) in bacteria form regulons. Here, we present a 4-step
method to fully reconstruct the leucine-responsive protein (Lrp) regulon in Escherichia coli K …

Type 1 fimbriae are a crucial factor for the virulence of uropathogenic Escherichia coli during
the first steps of infection by mediating adhesion to epithelial cells. They are also required for …

Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections in
women, causing significant morbidity and mortality in this population. Adherence to host …

Pathogenic bacteria sense environmental cues, including the local temperature, to control
the production of key virulence factors. Thermal regulation can be achieved at the level of …

Clostridium difficile is a leading cause of nosocomial infections, causing disease that ranges
from mild diarrhea to potentially fatal colitis. A variety of surface proteins, including flagella …

Reversible inversion of the DNA element fimS is responsible for the phase variable
expression of type 1 fimbriae in Escherichia coli. The FimB tyrosine integrase site‐specific …

Horizontal DNA transfer plays a major role in the evolution of bacteria. It allows them to
acquire new traits rapidly and these may confer fitness advantages as the bacteria compete …