Cardiovascular diseases are the leading cause of morbidity and mortality worldwide,
highlighting the high socioeconomic impact. Current treatment strategies like compound …

Skeletal muscle has gained recognition as an endocrine organ releasing myokines upon
contraction during physical exercise. These myokines exert both local and pleiotropic health …

Objective Recombinant adeno-associated virus (rAAV) vectors are powerful tools for the
sustained expression of proteins in vivo and have been successfully used for mechanistic …

Abstract Background Doxorubicin (Dox) is an effective chemotherapeutic drug for various
cancers, but its clinical application is limited by severe cardiotoxicity. Dox treatment can …

The ability to change an organism's DNA through gene editing is of great importance for the
prevention and treatment of genetic and acquired diseases. Rapid progress has been made …

Conventional rodent neuromyelitis optica spectrum disorder (NMOSD) models using patient-
derived immunoglobulin G (IgG) are potentially affected by the differences between the …

Background Obstructive sleep apnea (OSA) has been linked to various pathologies,
including arrhythmias such as atrial fibrillation. Specific treatment options for OSA are mainly …

Since its advent, gene-editing technology has been widely used in microorganisms,
animals, plants, and other species. This technology shows remarkable application …

心力衰竭是各种疾病的终末期, 是全世界发病率和死亡率的主要原因, 被称为心血管领域的最后“
战场”. 心力衰竭的发病机制多样复杂, 异常的心肌细胞钙循环是心力衰竭发生的主要病理生理 …

Background: Obstructive sleep apnea (OSA) has been linked to various pathologies,
including arrhythmias such as atrial fibrillation. Specific treatment options for OSA are mainly …