Abstract 3D printing alias additive manufacturing can transform 3D virtual models created by
computer-aided design (CAD) into physical 3D objects in a layer-by-layer manner …

Numerous studies to date have contributed to a paradigm shift in modeling cancer, moving
from the traditional two-dimensional culture system to three-dimensional (3D) culture …

Tumour microenvironment greatly influences the development and metastasis of cancer
progression. The development of three dimensional (3D) culture models which mimic that …

Angiogenesis, the outgrowth of blood vessels, is crucial in development, disease and
regeneration. Studying angiogenesis in vitro remains challenging because the capillary …

Metastasis is the cause of over 90% of all human cancer deaths. Early steps in the
metastatic process include: the formation of new blood vessels, the initiation of epithelial …

Angiogenesis, a crucial step in tumor growth and metastasis, is regulated by various pro-or
anti-angiogenic factors. Recently, microRNAs have been shown to modulate angiogenic …

A growing number of failing clinical trials for cancer therapy are substantiating the need to
upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in …

The establishment of tumor microenvironment using biomimetic in vitro models that
recapitulate key tumor hallmarks including the tumor supporting extracellular matrix (ECM) is …

Cancer metastases are a challenge for cancer treatment due to their organ specificity and
pathophysiological complexity. Engineering 3D in vitro models capable of replicating native …

Dormancy is recognized as a critical biological event for tumorigenic cells surviving in an
extremely harsh environment. Understanding the molecular process of dormancy can unlock …