Clonal haematopoiesis and dysregulation of the immune system
Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …
[HTML][HTML] DNA methyltransferases in cancer: biology, paradox, aberrations, and targeted therapy
J Zhang, C Yang, C Wu, W Cui, L Wang - Cancers, 2020 - mdpi.com
DNA methyltransferases are an essential class of modifiers in epigenetics. In mammals,
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …
[HTML][HTML] Acute myeloid leukemia with IDH1 and IDH2 mutations: 2021 treatment algorithm
GC Issa, CD DiNardo - Blood cancer journal, 2021 - nature.com
Acute myeloid leukemia is a genetically heterogeneous hematologic malignancy;
approximately 20% of AML harbors a mutation in the isocitrate dehydrogenase (IDH) genes …
approximately 20% of AML harbors a mutation in the isocitrate dehydrogenase (IDH) genes …
DNA methylation profiles in cancer diagnosis and therapeutics
Y Pan, G Liu, F Zhou, B Su, Y Li - Clinical and experimental medicine, 2018 - Springer
Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …
epigenetic modifications being increasingly identified as important targets for cancer …
[HTML][HTML] Mutant isocitrate dehydrogenase inhibitors as targeted cancer therapeutics
The identification of heterozygous neomorphic isocitrate dehydrogenase (IDH) mutations
across multiple cancer types including both solid and hematologic malignancies has …
across multiple cancer types including both solid and hematologic malignancies has …
[HTML][HTML] IDH mutations in cancer and progress toward development of targeted therapeutics
L Dang, K Yen, EC Attar - Annals of Oncology, 2016 - Elsevier
ABSTRACT Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes,
converting isocitrate to α-ketoglutarate (αKG). IDH1 and IDH2 mutations have been …
converting isocitrate to α-ketoglutarate (αKG). IDH1 and IDH2 mutations have been …
[HTML][HTML] Isocitrate dehydrogenase mutations in myeloid malignancies
BC Medeiros, AT Fathi, CD DiNardo, DA Pollyea… - Leukemia, 2017 - nature.com
Alterations to genes involved in cellular metabolism and epigenetic regulation are
implicated in the pathogenesis of myeloid malignancies. Recurring mutations in isocitrate …
implicated in the pathogenesis of myeloid malignancies. Recurring mutations in isocitrate …
[HTML][HTML] Epigenetic drivers of tumourigenesis and cancer metastasis
Since the completion of the first human genome sequence and the advent of next generation
sequencing technologies, remarkable progress has been made in understanding the …
sequencing technologies, remarkable progress has been made in understanding the …
[HTML][HTML] Clonal hematopoiesis: Mutation-specific adaptation to environmental change
MA Florez, BT Tran, TK Wathan, J DeGregori… - Cell Stem Cell, 2022 - cell.com
Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion
of genetically variant hematopoietic cells that increases exponentially with age and is …
of genetically variant hematopoietic cells that increases exponentially with age and is …
Molecular biomarkers in acute myeloid leukemia
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. The
pathophysiology of this disease is just beginning to be understood at the cellular and …
pathophysiology of this disease is just beginning to be understood at the cellular and …