Protein phosphorylation is a major control mechanism of a wide range of physiological
processes and plays an important role in cardiac pathophysiology. Serine/threonine protein …

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and its prevalence
increases with age. The irregular and rapid contraction of the atria can lead to ineffective …

Rationale: Atrial fibrillation (AF) causes atrial-tachycardia remodeling (ATR), with enhanced
constitutive acetylcholine-regulated K+ current (IKAChC) contributing to action potential …

CaMKII is a serine–threonine protein kinase that is abundant in myocardium. Emergent
evidence suggests that CaMKII may play an important role in promoting atrial fibrillation (AF) …

Abstract Aims TASK-1 (K2P3. 1) two-pore-domain potassium channels are atrial-specific
and significantly up-regulated in atrial fibrillation (AF) patients, contributing to AF-related …

Cardiac action potentials (APs) are driven by ionic currents flowing through specific
channels and exchangers across cardiomyocyte membranes. Once initiated by rapid Na+ …

Background and purpose This study was designed to establish the pathology-specific
inhibitory effects of the I Kur/I to/IK, ACh blocker AVE0118 on atrium-selective channels and …

Aims Although atrial tachycardia (AT) remodelling promotes agonist-independent,
constitutively active, acetylcholine-regulated K+-current (IK, ACh) that increases …

Small molecules interfering with Rac1 activation are considered as potential drugs and are
already studied in animal models. A widely used inhibitor without reported attenuation of …

Abstract G protein-gated K+(GIRK, or Kir3) channels mediate inhibitory neurotransmission
via G protein-coupled receptors (GPCRs) in heart and brain. The signaling cascade involves …