Chronic pain exerts an enormous personal and economic burden, affecting more than 30%
of people worldwide according to some studies. Unlike acute pain, which carries survival …

Over the past decade there has been an increasing reliance on strong opioids to treat acute
and chronic pain, which has been associated with a rising epidemic of prescription opioid …

Pain is the major symptom of osteoarthritis (OA) and is an important factor in strategies to
manage this disease. However, the current standard of care does not provide satisfactory …

Background Knee osteoarthritis (OA) is a chronic progressive disease that imparts a
substantial socioeconomic burden to society and healthcare systems. The prevalence of …

Osteoarthritis (OA) is the most common joint disease in the world, with an age-associated
increase in both incidence and prevalence. Clinical and epidemiologic research is crucial to …

Aim: To evaluate the efficacy of autologous adipose-derived mesenchymal stem cell
(ADMSC) therapy on pain, function and disease modification in knee osteoarthritis. Methods …

The nature of the transition from acute to chronic pain still eludes explanation, but chronic
pain resulting from surgery provides a natural experiment that invites clinical …

Background Several studies have identified clinical, psychosocial, patient characteristic, and
perioperative variables that are associated with persistent postsurgical pain; however, the …

Background Total hip or knee replacement is highly successful when judged by prosthesis-
related outcomes. However, some people experience long-term pain. Objectives To review …

Chronic pain is one of the most common conditions encountered by healthcare
professionals, particularly among older (≥ 65 years) patients. 1 Pain is associated with …