The tachykinin NK1 receptor is widely distributed in both the central and peripheral nervous
system. In the CNS, NK1 receptors have been implicated in various behavioural responses …

After its discovery in 1931, substance P (SP) remained the only mammalian member of the
family of tachykinin peptides for several decades. Tachykinins thus refer to peptides sharing …

Increasing evidence suggests that substance P (SP) and its receptor (neurokinin [NK]-1
receptor [NK1R]) might play an important role in the modulation of stress-related, affective …

Selective, nonpeptide antagonists for tachykinin receptors first became available ten years
ago. Of the three known tachykinin receptors, drug development has focused most …

The effects of tachykinin receptor agonists and antagonists were investigated using intra-
and extracellular recordings on spontaneously firing nigral neurons in guinea-pig brain …

The neurokinin 3 (NK3) receptor is predominantly expressed in the central nervous system
(CNS). Species differences in neurokinin 3 (NK3) receptor pharmacology have led to the …

The present article reviews the studies so far published on the psychopharmacological
effects mediated by tachykinin NK-3 receptors in laboratory animals. Central administration …

The classical tachykinins, substance P, neurokinin A and neurokinin B are predominantly
found in the nervous system where they act as neurotransmitters and neuromodulators …

This study characterized the novel neurokinin (NK) 1 antagonist, vestipitant, under clinical
evaluation for treatment of anxiety and depression. Vestipitant possessed high affinity for …

1 The effects of intracerebroventricular (icv) administration of the NK3 tachykinin receptor
agonist, senktide (10 nmol each side), in guinea‐pigs pretreated with the selective NK3 …