Early sensory experience instructs the maturation of neural circuitry in the cortex,. This has
been studied extensively in the primary visual cortex, in which loss of vision to one eye …

Mutations that cause intellectual disability (ID) and autism spectrum disorder (ASD) are
commonly found in genes that encode for synaptic proteins. However, it remains unclear …

Microglia have crucial roles in sculpting synapses and maintaining neural circuits during
development. To test the hypothesis that microglia continue to regulate neural circuit …

We developed and applied a Cre-dependent, genetically modified rabies-based tracing
system to map direct synaptic connections to specific CA1 neuron types in the mouse …

Adult-born dentate granule neurons contribute to memory encoding functions of the dentate
gyrus (DG) such as pattern separation. However, local circuit-mechanisms by which adult …

Physiological measurements in neuroscience experiments often involve complex stimulus
paradigms and multiple data channels. Ephus (http://www. ephus. org) is an open-source …

Loss-of-function mutations in CNTNAP2 cause a syndromic form of autism spectrum
disorder in humans and produce social deficits, repetitive behaviors, and seizures in mice …

Syngap1 haploinsufficiency is a common cause of sporadic intellectual disability. Syngap1
mutations disrupt developing pyramidal neurons, although it remains unclear if this process …

Subanesthetic ketamine evokes rapid and long-lasting antidepressant effects in human
patients. The mechanism for ketamine's effects remains elusive, but ketamine may broadly …

Key points Using functional mapping assays, we conducted a quantitative assessment of
both excitatory and inhibitory synaptic laminar connections to excitatory neurons in layers …