A series of fifteen new chemical entities, 3-(pyridin-4-yl)-1H-pyrazole-5-carboxamide
chalcones (6a–o), were synthesized as new hybrids with enriched biological activities …

In the current work, a series of novel 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate
hybrids (10a-o) and (11a-e) were synthesized and evaluated as new PPARα agonists in …

The Lewis acids of the sort ZnX 2 (X= Cl, Br, OTf & I) are rather simple and mild yet proves its
efficiency in enabling wide range of synthetic transformations in organic synthesis …

Inflammation therapy is particularly focused on the development of safer non-steroidal anti-
inflammatory drugs (NSAIDs), administered to control inflammation. It is typically considered …

Novel 3‐alkoxymethyl/3‐phenyl indole‐2‐carboxamide derivatives were synthesized and
evaluated for their anticancer activity. Most of the tested compounds showed moderate to …

The objective of this work was to obtain and evaluate anti-inflammatory in vitro, in vivo and in
silico potential of novel indole-N-acylhydrazone derivatives. In total, 10 new compounds (3a …

A wide number of marketed drugs and drug candidates in cancer clinical development
contain halogen substituents. The aim of the present study was to synthesize a series of …

Based on the importance of the previous fluorinated and/or hydroxylated chalcones studies,
thirty-six compounds were designed as phenyl or hydroxyphenyl bearing fluoro …

Background: A new set of hybrid conjugates derived from 2-(4-isobutylphenyl) propanoic
acid (ibuprofen) is synthesized to overcome the drawbacks of the current non-steroidal anti …

Abstract SARS‐CoV‐2 main protease (Mpro) plays an essential role in proteolysis cleavage
that promotes coronavirus replication. Thus, attenuating the activity of this enzyme …