Acetylcholinesterase (AChE) and beta-secretase (BACE-1) are two attractive targets in the
discovery of novel substances that could control multiple aspects of Alzheimer's disease …

Indole based glycosides belong to the class of pharmacologically active molecules and
found in diverse natural compounds. Herein, we report synthesis of 1, 2, 3-triazole bridged …

Inhibition of aldose reductase (ALR2) by using small heterocyclic compounds provides a
viable approach for the development of new antidiabetic agents. With our ongoing interest …

In an endeavor to identify potent anti‐inflammatory agents, new thiosemicarbazones (TSCs)
incorporated into a diaryl ether framework (2a–2l) were prepared and screened for their in …

The prevalence of obesity has increased dramatically worldwide leading to increases in
obesity-related complications, such as obesity-related glomerulopathy (ORG). Obesity is a …

An adequate enhancement in the development of resistance by microbial pathogens against
the available chemotherapeutic agents prompted us to find out some new chemotherapeutic …

Thiophenecarboxamide-α, β-unsaturated ketone (TCKs) hybrids were synthesized and
scrupulously characterized by nuclear magnetic resonance spectroscopy (NMR) by the …

Five new series of hydroxybenzofuranyl-pyrazolyl chalcones 3a, b, hydroxyphenyl-pyrazolyl
chalcones 6a–c and their corresponding pyrazolylpyrazolines 4a, d, 7a–c and 8a–f have …

Efficacy of current therapies for advanced and metastatic cancers remains a challenge in
clinical practice. We investigated the anti-cancer potency of 3 novel indoly-chalcones (CITs) …

The present work describes a novel approach for the annulation of an indole moiety onto the
1, 3-diaryl-2-propen-1-one scaffold followed by trifluoroacetylation of the resultant indole …