Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy

AG Singal, F Kanwal, JM Llovet - Nature reviews Clinical oncology, 2023 - nature.com
Hepatocellular carcinoma (HCC) mortality rates are increasing globally, and particularly in
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …

Epidemiology and risk-stratification of NAFLD-associated HCC

GN Ioannou - Journal of hepatology, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is projected to become the leading cause of
hepatocellular carcinoma (HCC) in many countries. Many risk factors for NAFLD are also …

AASLD practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma

AG Singal, JM Llovet, M Yarchoan, N Mehta… - Hepatology, 2023 - journals.lww.com
This guidance document provides an updated approach to the prevention, diagnosis, and
treatment of hepatocellular carcinoma (HCC). The prior American Association for the Study …

Current therapies and new developments in NASH

JF Dufour, QM Anstee, E Bugianesi, S Harrison… - Gut, 2022 - gut.bmj.com
Non-alcoholic steatohepatitis is becoming the most important aetiology for advanced liver
disease. There has been important progress in the field in recent years and the complexity of …

Targeting cancer-promoting inflammation—have anti-inflammatory therapies come of age?

J Hou, M Karin, B Sun - Nature reviews Clinical oncology, 2021 - nature.com
The immune system has crucial roles in cancer development and treatment. Whereas
adaptive immunity can prevent or constrain cancer through immunosurveillance, innate …

Trial design and endpoints in hepatocellular carcinoma: AASLD consensus conference

JM Llovet, A Villanueva, JA Marrero, M Schwartz… - …, 2021 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality
worldwide.(1, 2) This neoplasm has some unique characteristics. It occurs in most cases …

Side effects of statins: from pathophysiology and epidemiology to diagnostic and therapeutic implications

M Ruscica, N Ferri, M Banach, CR Sirtori… - Cardiovascular …, 2022 - academic.oup.com
Abstract Treatment with statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A
reductase, has proven beneficial preventive effects on cardiovascular events. However …

Fibrosis regression after eradication of hepatitis C virus: from bench to bedside

DC Rockey, SL Friedman - Gastroenterology, 2021 - Elsevier
Hepatitis C virus (HCV) infection and its complications have been the major cause of
cirrhosis and its complications for several decades in the Western world. Until recently …

Non-alcoholic fatty liver disease in children and young adults is associated with increased long-term mortality

TG Simon, B Roelstraete, K Hartjes, U Shah… - Journal of …, 2021 - Elsevier
Background & Aims Longitudinal data are scarce regarding the natural history and long-term
risk of mortality in children and young adults with biopsy-confirmed non-alcoholic fatty liver …

Cirrhosis as new indication for statins

J Bosch, J Gracia-Sancho, JG Abraldes - Gut, 2020 - gut.bmj.com
In the recent years, there have been an increasing number of reports on favourable effects of
statins in patients with advanced chronic liver disease. These include reduction in portal …