Glutathione in ovarian cancer: a double-edged sword
SC Nunes, J Serpa - International journal of molecular sciences, 2018 - mdpi.com
Glutathione (GSH) has several roles in a cell, such as a reactive oxygen species (ROS)
scavenger, an intervenient in xenobiotics metabolism and a reservoir of cysteine. All of these …
scavenger, an intervenient in xenobiotics metabolism and a reservoir of cysteine. All of these …
Mitochondria, lysosomes, and dysfunction: their meaning in neurodegeneration
M Audano, A Schneider, N Mitro - Journal of neurochemistry, 2018 - Wiley Online Library
In the last decades, lysosomes and mitochondria were considered distinct and physically
separated organelles involved in different cellular functions. While lysosomes were thought …
separated organelles involved in different cellular functions. While lysosomes were thought …
Mitochondrial–lysosomal axis in acetaminophen hepatotoxicity
Acetaminophen (APAP) toxicity is the most common cause of acute liver failure and a major
indication for liver transplantion in the United States and Europe. Although significant …
indication for liver transplantion in the United States and Europe. Although significant …
Lysosomal and mitochondrial liaisons in Niemann-Pick disease
Lysosomal storage disorders (LSD) are characterized by the accumulation of diverse lipid
species in lysosomes. Niemann-Pick type A/B (NPA/B) and type C diseases Niemann-Pick …
species in lysosomes. Niemann-Pick type A/B (NPA/B) and type C diseases Niemann-Pick …
Annexin animal models—from fundamental principles to translational research
Routine manipulation of the mouse genome has become a landmark in biomedical
research. Traits that are only associated with advanced developmental stages can now be …
research. Traits that are only associated with advanced developmental stages can now be …
[HTML][HTML] MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content
MLN64 is a late endosomal cholesterol-binding membrane protein that has been implicated
in cholesterol transport from endosomal membranes to the plasma membrane and/or …
in cholesterol transport from endosomal membranes to the plasma membrane and/or …
Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia
J Hlouschek, V Ritter, F Wirsdörfer, D Klein… - Cancer letters, 2018 - Elsevier
High tumor heterogeneity and increased therapy resistance acquired in a hypoxic tumor
microenvironment remain major obstacles to successful radiotherapy. Others and we have …
microenvironment remain major obstacles to successful radiotherapy. Others and we have …
[HTML][HTML] Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial …
S Torres, E Solsona-Vilarrasa, S Nuñez, N Matías… - Redox Biology, 2021 - Elsevier
Abstract Niemann-Pick type C (NPC) disease, a lysosomal storage disorder caused by
defective NPC1/NPC2 function, results in the accumulation of cholesterol and …
defective NPC1/NPC2 function, results in the accumulation of cholesterol and …
[HTML][HTML] The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading
Cancer cells exhibit mitochondrial cholesterol (mt-cholesterol) accumulation, which
contributes to cell death resistance by antagonizing mitochondrial outer membrane (MOM) …
contributes to cell death resistance by antagonizing mitochondrial outer membrane (MOM) …
The pathogenesis of lysosomal storage disorders: beyond the engorgement of lysosomes to abnormal development and neuroinflammation
There is growing evidence that the complex clinical manifestations of lysosomal storage
diseases (LSDs) are not fully explained by the engorgement of the endosomal-autophagic …
diseases (LSDs) are not fully explained by the engorgement of the endosomal-autophagic …