Differential Effects of Glycyrrhiza Species on Genotoxic Estrogen Metabolism: Licochalcone A Downregulates P450 1B1, whereas Isoliquiritigenin Stimulates It
Estrogen chemical carcinogenesis involves 4-hydroxylation of estrone/estradiol (E1/E2) by
P450 1B1, generating catechol and quinone genotoxic metabolites that cause DNA …
P450 1B1, generating catechol and quinone genotoxic metabolites that cause DNA …
Recent advancement in drug development of nitro(NO2)‐heterocyclic compounds as lead scaffolds for the treatment of Mycobacterium tuberculosis
Tuberculosis (TB) is an infectious disease caused predominantly by Mycobacterium
tuberculosis (Mtb). It was responsible for approximately 1.4 million deaths worldwide in …
tuberculosis (Mtb). It was responsible for approximately 1.4 million deaths worldwide in …
Nitroxyl (HNO): a possible strategy for fighting cancer
Nitroxyl (HNO), the one electron reduced form of nitric oxide (NO), shows a very distinct
chemistry and biology from that of NO. Chemical profile is characterized by reactions with …
chemistry and biology from that of NO. Chemical profile is characterized by reactions with …
NO‐sulindac inhibits the hypoxia response of PC‐3 prostate cancer cells via the Akt signalling pathway
GD Stewart, J Nanda, DJG Brown… - … Journal of Cancer, 2009 - Wiley Online Library
Nitric oxide‐donating non‐steroidal anti‐inflammatory drugs are safer than traditional
NSAIDs and inhibit the growth of prostate cancer cells with greater potency than NSAIDs. In …
NSAIDs and inhibit the growth of prostate cancer cells with greater potency than NSAIDs. In …
Novel nitric oxide donor, nitrated phenylbutyrate, induces cell death of human pancreatic cancer cells and suppresses tumor growth of cancer xenografts
T Beppu, K Nishi, S Imoto, W Araki… - Oncology …, 2022 - spandidos-publications.com
Pancreatic cancer has a low response rate to chemotherapy due to the low drug
transferability caused by the low blood flow around the tumor. In the present study, focusing …
transferability caused by the low blood flow around the tumor. In the present study, focusing …
Prodrugs Bioactivated to Quinones Target NF-κB and Multiple Protein Networks: Identification of the Quinonome
EN Pierce, SC Piyankarage, T Dunlap… - Chemical research in …, 2016 - ACS Publications
Electrophilic reactive intermediates resulting from drug metabolism have been associated
with toxicity and off-target effects and in some drug discovery programs trigger NO-GO …
with toxicity and off-target effects and in some drug discovery programs trigger NO-GO …
Differential inhibition of tumour cell‐induced platelet aggregation by the nicotinate aspirin prodrug (ST0702) and aspirin
C Medina, S Harmon, I Inkielewicz… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE Tumour cell‐induced platelet aggregation (TCIPA)
facilitates cancer cell invasion, angiogenesis and the formation of metastatic foci. TCIPA can …
facilitates cancer cell invasion, angiogenesis and the formation of metastatic foci. TCIPA can …
Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention
GK Hagos, SO Abdul-Hay, J Sohn, PD Edirisinghe… - Molecular …, 2008 - ASPET
Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown promise in colorectal cancer
(CRC), but they are compromised by gastrotoxicity. NO-NSAIDs are hybrid nitrates …
(CRC), but they are compromised by gastrotoxicity. NO-NSAIDs are hybrid nitrates …
Chemopreventive activity of bioactive fungal fractions isolated from milk-supplemented cultures of Cerrena unicolor and Pycnoporus sanguineus on colon cancer …
M Pięt, A Zając, R Paduch, M Jaszek, M Frant… - 3 Biotech, 2021 - Springer
The biochemical properties and anti-tumorigenic activity of Cerrena unicolor (CU) and
Pycnoporus sanguineus (PS) towards colon cancer cells and the effect of supplementation …
Pycnoporus sanguineus (PS) towards colon cancer cells and the effect of supplementation …
NCX 4040, a nitric oxide-donating aspirin, exerts anti-inflammatory effects through inhibition of IκB-α degradation in human monocytes
E Ricciotti, M Dovizio, L Di Francesco… - The journal of …, 2010 - journals.aai.org
NO-donating aspirins consist of aspirin to which a NO-donating group is covalently linked
via a spacer molecule. NCX 4040 and NCX 4016 are positional isomers with respect to the …
via a spacer molecule. NCX 4040 and NCX 4016 are positional isomers with respect to the …