Quantifying gait and postural control adds valuable information that aids in understanding
neurological conditions where motor symptoms predominate and cause considerable …

Spinocerebellar ataxia (SCA) comprises a large group of heterogeneous neurodegenerative
disorders inherited in an autosomal dominant fashion. It is characterized by progressive …

Hereditary ataxias, especially when presenting sporadically in adulthood, present a
particular diagnostic challenge owing to their great clinical and genetic heterogeneity …

Abstract Spinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease that
manifests in midlife and progressively worsens with age. SCA6 is rare, and many patients …

The cause of downbeat nystagmus (DBN) remains unknown in approximately 30% of
patients (idiopathic DBN). Here, we hypothesized that:(i) FGF14 (GAA)≥ 250 repeat …

Background Cerebellar damage can often result in disabilities affecting the peripheral
regions of the body. These include poor and inaccurate coordination, tremors and irregular …

Essential tremor (ET) has recently been reconceptualized by many as a degenerative
disease of the cerebellum. Until now, though, there has been no attempt to frame it within the …

Dysphagia, which can lead to nutritional deficiencies, weight loss and dehydration,
represents a risk factor for aspiration pneumonia. Although clinical studies have reported the …

Dysphagia is a common symptom in neurodegenerative disorders and is generally
associated with increased mortality. In the clinical care setting of ataxia patients, no …

Abstract Spinocerebellar ataxia type 6 (SCA6) is an autosomal dominant neurodegenerative
disease caused by a small polyglutamine (polyQ) expansion (control: 4–20Q; SCA6: 20 …