Lung cancer is among the most common cancers with a high mortality rate worldwide.
Despite the significant advances in diagnostic and therapeutic approaches, lung cancer …

While the epithelial-mesenchymal transition (EMT) plays a fundamental role during
development, its deregulation can adversely promote tumor metastasis. The phenotypic and …

This study explores the roles of genome copy number abnormalities (CNAs) in breast cancer
pathophysiology by identifying associations between recurrent CNAs, gene expression, and …

DNA methylation is an important epigenetic modification of DNA in mammalian genomes.
DNA methylation patterns are established early in development, modulated during tissue …

Background: The concept of CpG island methylator phenotype (CIMP) is not universally
accepted. Even if specific clinicopathological features have been associated with CIMP …

Purpose: The DNA methylation paradox, manifested as derepression of cancer-testis
antigens, and silencing of tumor suppressors during malignant transformation, provides the …

Age is the most important risk factor for tumorigenesis. More than 60% of new cancers and
more than 70% of cancer deaths occur in elderly subjects> 65 years. The immune system …

Head-and-neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide, and its incidence is growing. Although environmental carcinogens and …

Gemcitabine is currently the leading therapeutic for pancreatic cancer treatment, despite
growing resistance. Studying the mechanisms that underlie gemcitabine resistance and …

Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5, 10-
methylenetetrahydofolate (CH2-H4folate) to 5-methyltetrahydrofolate (CH3-H4folate). The …