Nanoparticles as drug delivery systems

AZ Wilczewska, K Niemirowicz, KH Markiewicz… - Pharmacological …, 2012 - Elsevier
Controlled drug delivery systems (DDS) have several advantages compared to the
traditional forms of drugs. A drug is transported to the place of action, hence, its influence on …

Chemical basis of interactions between engineered nanoparticles and biological systems

Q Mu, G Jiang, L Chen, H Zhou, D Fourches… - Chemical …, 2014 - ACS Publications
As defined by the European Commission, a nanomaterial is a natural, an incidental, or a
manufactured material containing particles in an unbound state or as an aggregate or …

Nonporous silica nanoparticles for nanomedicine application

L Tang, J Cheng - Nano today, 2013 - Elsevier
Nanomedicine, the use of nanotechnology for biomedical applications, has potential to
change the landscape of the diagnosis and therapy of many diseases. In the past several …

Toxicity of silica nanoparticles depends on size, dose, and cell type

IY Kim, E Joachim, H Choi, K Kim - … : Nanotechnology, Biology and Medicine, 2015 - Elsevier
Monodisperse spherical silica nanoparticles (SNPs) with diameters of 20–200 nm were
employed to study size, dose, and cell-type dependent cytotoxicity in A549 and HepG2 …

The nanosilica hazard: another variable entity

D Napierska, LCJ Thomassen, D Lison… - Particle and fibre …, 2010 - Springer
Silica nanoparticles (SNPs) are produced on an industrial scale and are an addition to a
growing number of commercial products. SNPs also have great potential for a variety of …

Understanding nanoparticle cellular entry: a physicochemical perspective

CM Beddoes, CP Case, WH Briscoe - Advances in colloid and interface …, 2015 - Elsevier
Understanding interactions between nanoparticles (NPs) with biological matter, particularly
cells, is becoming increasingly important due to their growing application in medicine and …

Metal‐based nanoparticles and their toxicity assessment

AM Schrand, MF Rahman, SM Hussain… - Wiley …, 2010 - Wiley Online Library
Nanoparticles (NPs) can potentially cause adverse effects on organ, tissue, cellular,
subcellular, and protein levels due to their unusual physicochemical properties (eg, small …

Impacts of mesoporous silica nanoparticle size, pore ordering, and pore integrity on hemolytic activity

YS Lin, CL Haynes - Journal of the American Chemical Society, 2010 - ACS Publications
This paper uses the measure of hemolysis to evaluate the toxicity of nonporous and porous
silica nanoparticles with varied sizes and investigates the effects of porous structure and …

Copper oxide nanoparticles induced mitochondria mediated apoptosis in human hepatocarcinoma cells

MA Siddiqui, HA Alhadlaq, J Ahmad, AA Al-Khedhairy… - PloS one, 2013 - journals.plos.org
Copper oxide nanoparticles (CuO NPs) are heavily utilized in semiconductor devices, gas
sensor, batteries, solar energy converter, microelectronics and heat transfer fluids. It has …

Surface charge of gold nanoparticles mediates mechanism of toxicity

NM Schaeublin, LK Braydich-Stolle, AM Schrand… - Nanoscale, 2011 - pubs.rsc.org
Recently gold nanoparticles (Au NPs) have shown promising biological and military
applications due to their unique electronic and optical properties. However, little is known …