Protein structure prediction is a longstanding issue crucial for identifying new drug targets
and providing a mechanistic understanding of protein functions. To enhance the progress in …

In this review, we describe the creation of the Nucleic Acid Database (NDB) at Rutgers
University and how it became a testbed for the current infrastructure of the RCSB Protein …

Quadruplexes (G4s) are of interest, which increases with the number of identified G4
structures and knowledge about their biomedical potential. These unique motifs form in …

Background Single-stranded nucleic acids (ssNAs) have important biological roles and a
high biotechnological potential linked to their ability to bind to numerous molecular targets …

ONQUADRO is an advanced database system that supports the study of the structures of
canonical and non-canonical quadruplexes. It combines a relational database that collects …

Abstract G-quadruplex (G4), a non-canonical nucleic acid structure, has been suggested to
play a key role in important cellular processes including transcription, replication and cancer …

Background: Diabetic kidney disease (DKD) becomes the leading cause of death for end-
stage renal disease, whereas the potential mechanism is unclear and effective therapy is …

Modulation of structural and thermodynamic properties of nucleic acids with synthetic
modifications is a promising area of research with possible applications in nanotechnology …

Visualizing vibrational motions calculated with different ab initio packages requires
dedicated post-processing tools. Here, we present a PyMOL plugin called PyVibMS for …

Motivation Mutations that alter protein–DNA interactions may be pathogenic and cause
diseases. Therefore, it is extremely important to quantify the effect of mutations on protein …