ADME and pharmacokinetic properties of remdesivir: its drug interaction potential
S Deb, AA Reeves, R Hopefl, R Bejusca - Pharmaceuticals, 2021 - mdpi.com
On 11 March 2020, the World Health Organization (WHO) classified the Coronavirus
Disease 2019 (COVID-19) as a global pandemic, which tested healthcare systems …
Disease 2019 (COVID-19) as a global pandemic, which tested healthcare systems …
Non-P450 drug-metabolizing enzymes: contribution to drug disposition, toxicity, and development
T Fukami, T Yokoi, M Nakajima - Annual Review of …, 2022 - annualreviews.org
Most clinically used drugs are metabolized in the body via oxidation, reduction, or hydrolysis
reactions, which are considered phase I reactions. Cytochrome P450 (P450) enzymes …
reactions, which are considered phase I reactions. Cytochrome P450 (P450) enzymes …
[HTML][HTML] Potential herb‒drug interactions between anti-COVID-19 drugs and traditional Chinese medicine
L Ye, S Fan, P Zhao, C Wu, M Liu, S Hu, P Wang… - … Pharmaceutica Sinica B, 2023 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide. Effective treatments against …
syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide. Effective treatments against …
Prediction of carboxylesterase 1-mediated in vivo drug interaction between methylphenidate and cannabinoids using static and physiologically based …
Y Qian, JS Markowitz - Drug Metabolism and Disposition, 2022 - ASPET
The use of cannabis products has increased substantially. Cannabis products have been
perceived and investigated as potential treatments for attention-deficit/hyperactivity disorder …
perceived and investigated as potential treatments for attention-deficit/hyperactivity disorder …
Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2
YQ Song, RJ He, D Pu, XQ Guan, JH Shi… - Frontiers in …, 2021 - frontiersin.org
Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the
small intestine, has been validated as a key therapeutic target to ameliorate the intestinal …
small intestine, has been validated as a key therapeutic target to ameliorate the intestinal …
Hormetic effects of EGC and EGCG on CES1 activity and its rescue from oxidative stress in rat liver S9
X Luo, F Lu, Z Yin, Z Zhou, Z Wang, H Zhang - Chemico-Biological …, 2023 - Elsevier
Abstract Carboxylesterase 1 (CES1) is a hydrolytic enzyme that plays an important role in
the activation or deactivation of many therapeutic agents, thus affecting their …
the activation or deactivation of many therapeutic agents, thus affecting their …
[HTML][HTML] The influence of cannabidiol on the pharmacokinetics of methylphenidate in healthy subjects
JS Markowitz, L De Faria, Q Zhang… - Medical Cannabis and …, 2022 - karger.com
Introduction: Cannabidiol (CBD) is a widely utilized nonpsychoactive cannabinoid available
as an over-the-counter supplement, a component of medical cannabis, and a prescriptive …
as an over-the-counter supplement, a component of medical cannabis, and a prescriptive …
In vitro inhibition of carboxylesterase 1 by Kava (Piper methysticum) Kavalactones
Kava refers to the extracts from the rhizome of the plant Piper methysticum which is of
particular significance to various indigenous cultures in the South Pacific region …
particular significance to various indigenous cultures in the South Pacific region …
Natural products: Experimental approaches to elucidate disposition mechanisms and predict pharmacokinetic drug interactions
MF Paine - Drug Metabolism and Disposition, 2020 - ASPET
Natural products have been used by humans since antiquity for both egregious and
beneficial purposes. Regarding the latter, these products have long been valued as a rich …
beneficial purposes. Regarding the latter, these products have long been valued as a rich …
Regulation of carboxylesterases and its impact on pharmacokinetics and pharmacodynamics: an up-to-date review
ABSTRACT Introduction Carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …